Common prefrontal regions coactivate with dissociable posterior regions during controlled semantic and phonological tasks
Common prefrontal regions coactivate with dissociable posterior regions during controlled semantic and phonological tasks
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DOI：
10.1016/s0896-6273(02)00800-0
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发表时间：
2002-08-15
期刊：
影响因子：
16.2
通讯作者：
Buckner, RL
中科院分区：
文献类型：
--
作者：
Gold, BT;Buckner, RL
功能神经影像学研究中最普遍的发现之一是，在需要控制语义检索的任务中，左下前额叶皮层（LIPC）被激活。在这里，我们展示了LIPC参与非语义表征和语义表征的受控检索。结果还表明，LIPC与可分离的后部区域共同激活，这取决于所检索的信息：在语义受控检索期间与左侧颞叶皮层激活，在语音受控检索期间与左侧额叶和顶叶后皮层激活。表现与LIPC激活的相关性表明，在语义和语音任务中，与映射相对模糊的刺激-表征关系有关的加工作用。这些发现表明，LIPC参与了多个信息域的受控加工，并根据检索到的信息类型与可分离的后脑区合作。
One of the most ubiquitous findings in functional neuroimaging research is activation of left inferior prefrontal cortex (LIPC) during tasks requiring controlled semantic retrieval. Here we show that LIPC participates in the controlled retrieval of nonsemantic representations as well as semantic representations. Results also demonstrate that LIPC coactivates with dissociable posterior regions depending on the information retrieved: activating with left temporal cortex during the controlled retrieval of semantics and with left posterior frontal and parietal cortex during the controlled retrieval of phonology. Correlation of performance to LIPC activation suggests a processing role associated with mapping relatively ambiguous stimulus-to-representation relationships during both semantic and phonological tasks. These findings suggest that LIPC participates in controlled processing across multiple information domains collaborating with dissociable posterior regions depending upon the kind of information retrieved.