Gene expression response in target organ and whole blood varies as a function of target organ injury phenotype.
Gene expression response in target organ and whole blood varies as a function of target organ injury phenotype.
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DOI：
10.1186/gb-2008-9-6-r100
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发表时间：
2008
期刊：
影响因子：
12.3
通讯作者：
Paules, Richard S.
中科院分区：
文献类型：
--
作者：
Lobenhofer, Edward K.;Auman, J. Todd;Blackshear, Pamela E.;Boorman, Gary A.;Bushel, Pierre R.;Cunningham, Michael L.;Fostel, Jennifer M.;Gerrish, Kevin;Heinloth, Alexandra N.;Irwin, Richard D.;Malarkey, David E.;Merrick, B. Alex;Sieber, Stella O.;Tucker, Charles J.;Ward, Sandra M.;Wilson, Ralph E.;Hurban, Patrick;Tennant, Raymond W.;Paules, Richard S.
采用八种已知肝毒素治疗大鼠肝脏和血液，收集其组织病理学、临床化学、血液学和基因表达数据。本报告详细介绍了标准化实验设计和使用八种已知肝毒物（在多个时间点和剂量下进行多个生物重复）治疗后收集的不同数据流（来自目标组织（肝脏）和生物可用组织（血液）的组织病理学、临床化学、血液学和基因表达）。研究结果证明了组织病理学差异的分类，可能反映了细胞特异性毒性机制的差异，使用肝组织或血液转录组数据。
Histopathology, clinical chemistry, hematology and gene expression data were collected from the rat liver and blood after treatment with eight known hepatotoxins. This report details the standardized experimental design and the different data streams that were collected (histopathology, clinical chemistry, hematology and gene expression from the target tissue (liver) and a bio-available tissue (blood)) after treatment with eight known hepatotoxicants (at multiple time points and doses with multiple biological replicates). The results of the study demonstrate the classification of histopathological differences, likely reflecting differences in mechanisms of cell-specific toxicity, using either liver tissue or blood transcriptomic data.
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影响因子：
3.8
作者：
Hamadeh, HK;Bushel, PR;Afshari, CA
通讯作者：
Afshari, CA
影响因子：
1.5
作者：
Hamadeh, HK;Knight, BL;Paules, RS
通讯作者：
Paules, RS
影响因子：
3.8
作者：
Beyer, Richard P.;Fry, Rebecca C.;Zarbl, Helmut
通讯作者：
Zarbl, Helmut
影响因子：
3.8
作者：
Gujral, JS;Farhood, A;Jaeschke, H
通讯作者：
Jaeschke, H
影响因子：
3.8
作者：
Hissink, AM;VanOmmen, B;VanBladeren, PJ
通讯作者：
VanBladeren, PJ