EVIDENCE FOR ABERRANT AUDITORY ANATOMY IN DEVELOPMENTAL DYSLEXIA
EVIDENCE FOR ABERRANT AUDITORY ANATOMY IN DEVELOPMENTAL DYSLEXIA
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DOI：
10.1073/pnas.91.17.8010
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发表时间：
1994-08-16
影响因子：
11.1
通讯作者：
ROSEN, GD
中科院分区：
文献类型：
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作者：
GALABURDA, AM;MENARD, MT;ROSEN, GD
阅读障碍患者的异常听觉处理提示听觉系统可能存在伴随的解剖学异常。因此，我们测量了横截面的内侧膝状体核（MGNs）的神经元面积的5个睡眠障碍和7个对照组的大脑。对照组没有表现出不对称性，与之相反，在睡眠障碍样本中，左侧MGN神经元明显小于右侧。与对照组相比，左侧睡眠障碍MGN内小神经元增多，大神经元减少。这些发现与报道的基于左半球的语音缺陷在睡眠障碍个体的行为结果是一致的。
Abnormal auditory processing in dyslexics suggests that accompanying anatomical abnormalities might be present in the auditory system. Therefore, we measured cross-sectional neuronal areas in the medial geniculate nuclei (MGNs) of five dyslexic and seven control brains. In contrast to controls, which showed no asymmetry, the left-side MGN neurons were significantly smaller than the right in the dyslexic sample. Also, as compared with controls, there were more small neurons and fewer large neurons in the left dyslexic MGN. These findings are consistent with reported behavioral findings of a left hemisphere-based phonological defect in dyslexic individuals.