Regulatory T Cell Stability and Plasticity in Atherosclerosis.
Regulatory T Cell Stability and Plasticity in Atherosclerosis.
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作者：
Ali AJ;Makings J;Ley K
调节性T细胞(Tregs)表达家族决定转录因子FoxP3，在自身耐受和免疫动态平衡中发挥重要作用。胸腺tTregs是基于对自身抗原的亲和力而选择的，在大多数情况下都是稳定的。在转化生长因子-β和其他细胞因子的影响下，外周血pTregs与传统的CD4T细胞分化，稳定性较差。Treg可塑性是指它们能够诱导表达辅助性CD4T细胞系特有的分子，如辅助性T细胞(Th)1、Th2、Th17或滤泡辅助性T细胞。塑料树保留了FoxP3，被认为是“它们”血统的专门调节器。不稳定的Tregs失去FoxP3，转而成为exTregs，从而获得促炎T辅助细胞程序。动脉粥样硬化伴有全身性高脂血症、高胆固醇血症、炎性细胞因子和局部缺氧，为Tregs转换为exTregs提供了可能的环境。
Regulatory T cells (Tregs) express the lineage-defining transcription factor FoxP3 and play crucial roles in self-tolerance and immune homeostasis. Thymic tTregs are selected based on affinity for self-antigens and are stable under most conditions. Peripheral pTregs differentiate from conventional CD4 T cells under the influence of TGF-β and other cytokines and are less stable. Treg plasticity refers to their ability to inducibly express molecules characteristic of helper CD4 T cell lineages like T-helper (Th)1, Th2, Th17 or follicular helper T cells. Plastic Tregs retain FoxP3 and are thought to be specialized regulators for “their” lineage. Unstable Tregs lose FoxP3 and switch to become exTregs, which acquire pro-inflammatory T-helper cell programs. Atherosclerosis with systemic hyperlipidemia, hypercholesterolemia, inflammatory cytokines, and local hypoxia provides an environment that is likely conducive to Tregs switching to exTregs.
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影响因子：
64.8
作者：
Bettelli, E;Carrier, YJ;Kuchroo, VK
通讯作者：
Kuchroo, VK
影响因子：
4.4
作者：
Burchill, Matthew A.;Yang, Jianying;Farrar, Michael A.
通讯作者：
Farrar, Michael A.
控制FOXP3基因座中的顺式元素对调节T细胞身份的遗传控制。
影响因子：
64.5
作者：
Feng Y;Arvey A;Chinen T;van der Veeken J;Gasteiger G;Rudensky AY
通讯作者：
Rudensky AY
DOI：
10.1006/bbrc.1997.7124
发表时间：
1997-08-28
影响因子：
3.1
作者：
Feil, R;Wagner, J;Chambon, P
通讯作者：
Chambon, P
影响因子：
32.4
作者：
Bailey-Bucktrout, Samantha L.;Martinez-Llordella, Marc;Zhou, Xuyu;Anthony, Bryan;Rosenthal, Wendy;Luche, Herve;Fehling, Hans J.;Bluestone, Jeffrey A.
通讯作者：
Bluestone, Jeffrey A.