Graded unilateral cervical spinal cord injury and respiratory motor recovery
Graded unilateral cervical spinal cord injury and respiratory motor recovery
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DOI：
10.1016/j.resp.2008.12.010
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发表时间：
2009-02-28
影响因子：
2.3
通讯作者：
Reier, P. J.
中科院分区：
文献类型：
--
作者：
Fuller, D. D.;Sandhu, M. S.;Reier, P. J.
我们研究了大鼠慢性（1个月）单侧C2脊髓损伤（SCI）后腹内侧（VM）组织保留对呼吸恢复的潜在贡献。相对于对侧白色物质，定量表达损伤同侧保留的白色物质。完全C2半切（C2 HS）后同侧与对侧白色物质比率为0，VM保留最少时为0.23 +/- 0.04。分别通过体积描记法（清醒大鼠）和膈神经电图（麻醉大鼠）测量的吸气（呼吸min（-1））和膈频率（爆发min（-1））均较低，VM保留最少（p
We examined the potential contribution of ventromedial (VM) tissue sparing to respiratory recovery following chronic (1 mo) unilateral C2 spinal cord injury (SCI) in rats. Preserved white matter ipsilateral to the injury was quantitatively expressed relative to contralateral white matter. The ipsilateral-to-contralateral white matter ratio was 0 after complete C2 hemisection (C2HS) and 0.23 +/- 0.04 with minimal VM sparing. Inspiratory (breath min(-1)) and phrenic frequency (burst min(-1)), measured by plethysmography (conscious rats) and phrenic neurograms (anesthetized rats) respectively, were both lower with minimal VM sparing (p