Anti-aquaporin-4 auto-antibodies orchestrate the pathogenesis in neuromyelitis optica
Anti-aquaporin-4 auto-antibodies orchestrate the pathogenesis in neuromyelitis optica
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DOI：
10.1016/j.autrev.2009.04.004
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发表时间：
2009-12-01
影响因子：
13.6
通讯作者：
Vincent, Thierry
中科院分区：
文献类型：
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作者：
Saikali, Philippe;Cayrol, Romain;Vincent, Thierry
NMO-IgG是与自身免疫性炎症性疾病视神经肌萎缩症（NMO）相关的水通道蛋白-4（AQP 4）水通道特异性自身抗体，被认为是准确的血清生物标志物，并且被认为是NMO病理学的重要贡献者。在这篇综述中，我们总结了最近的证据，从我们的小组和其他人表明，NMO-IgG可以牵连在几个层次上的免疫病理学的NMO。NMO-IgG/抗AQP 4抗体可能损害血脑屏障的完整性，从而促进和增强NMO的血管周围炎症特征。最后，NMO-IgG可以诱导星形胶质细胞损伤，这可能导致兴奋性/毒性分子的积累，从而损伤少突胶质细胞并损害髓鞘完整性。(C)2009 Elsevier B. V.保留所有权利。
NMO-IgG, the auto-antibody specific to the aquaporin-4 (AQP4) water channel associated with the autoimmune inflammatory disease neuromyelitis optica (NMO), is considered to be an accurate serum biomarker and is thought to be an important contributor to NMO pathology. In this review, we summarize recent evidences from our group and others indicating that NMO-IgG can be implicated at several levels in the immuno-pathology of NMO. NMO-IgG/anti-AQP4 antibodies may compromise the integrity of the blood-brain barrier and consequently facilitate and enhance the perivascular inflammation characteristic of NMO. Lastly, NMO-IgG can induce astrocyte injury which may lead to the accumulation of excitatory/toxic molecules and accordingly damage oligodendrocytes and compromise myelin integrity. (C) 2009 Elsevier B.V. All rights reserved.