Association of ambulatory heart rate and atherosclerosis risk factors with blood pressure in young non-hypertensive adults.
Association of ambulatory heart rate and atherosclerosis risk factors with blood pressure in young non-hypertensive adults.
复制标题
动态心率和动脉粥样硬化危险因素与年轻非高血压成人血压的关联。
DOI：
10.1136/openhrt-2015-000332
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发表时间：
2016
期刊：
影响因子：
2.7
通讯作者：
Daskalakis,Constantine
中科院分区：
文献类型：
--
作者：
Cheng,Cynthia;Daskalakis,Constantine
研究的目的是评估24小时动态心率（HR），动脉粥样硬化危险因素和血压（BP）之间的关联在年轻的非高血压patients.MethodsWe招募了186名参与者，年龄在18-45岁，从一个大型城市学术家庭医学门诊实践，为40 000人这项观察性研究。 主要的分析是基于多元线性回归，平均24小时血压（收缩压（SBP）或舒张压（DBP））的结果，平均24小时HR的主要预测因素的利益，并控制年龄，性别，种族，胰岛素敏感性/抵抗和内皮功能测量应变计静脉闭塞plethysmography.ResultsHR是独立相关的平均24小时收缩压和舒张压（收缩压和舒张压：P=0.042和0.001，分别）。 在我们的分析中，与门诊血压测量相比，门诊血压测量的相关性明显更强。内皮功能障碍与较高的SBP相关（p=0.013）;纤溶酶原激活物抑制剂-1与SBP和DBP显著相关（分别为p=0.041和0.015），而胰岛素抵抗与SBP或DBP均无关。胰岛素抵抗和C反应蛋白是显着的HR预测因子（p=0.013和0.007，分别）。ConclusionsThese研究结果表明，HR可能是一个潜在的标志物的心血管风险升高的年轻无症状的个人，在发展临床高血压或心血管疾病。
ObjectiveThe study objective was to assess the association between 24 h ambulatory heart rate (HR), atherosclerosis risk factors and blood pressure (BP) in young non-hypertensive patients.MethodsWe recruited 186 participants aged 18–45 years from a large urban academic Family Medicine outpatient practice, serving 40 000 individuals for this observational study. The main analyses were based on multiple linear regression, with mean 24 h BP (systolic BP (SBP) or diastolic BP (DBP)) as the outcomes, mean 24 h HR as the main predictor of interest, and controlling for age, gender, race, insulin sensitivity/resistance and endothelial function measured by strain gauge venous occlusion plethysmography.ResultsHR was independently associated with mean 24 h SBP and DBP (SBP and DBP: p=0.042 and 0.001, respectively). In our analyses, associations were markedly stronger for ambulatory compared with office BP measurements. Endothelial dysfunction was associated with higher SBP (p=0.013); plasminogen activator inhibitor-1 was significantly associated with both SBP and DBP (p=0.041 and 0.015, respectively), while insulin resistance was not associated with either SBP or DBP. Insulin resistance and C reactive protein were significant predictors of HR (p=0.013 and 0.007, respectively).ConclusionsThese findings suggest that HR may be a potential marker of elevated cardiovascular risk in young asymptomatic individuals, prior to the development of clinical hypertension or cardiovascular disease.