SPATIAL CONTROL OF GUT-SPECIFIC GENE-EXPRESSION DURING CAENORHABDITIS-ELEGANS DEVELOPMENT
SPATIAL CONTROL OF GUT-SPECIFIC GENE-EXPRESSION DURING CAENORHABDITIS-ELEGANS DEVELOPMENT
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DOI：
10.1126/science.2020855
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发表时间：
1991-04-26
期刊：
影响因子：
56.9
通讯作者：
MCGHEE, JD
中科院分区：
文献类型：
--
作者：
AAMODT, EJ;CHUNG, MA;MCGHEE, JD
将含有肠道特异的GES-1羧酸酯酶基因上游缺失的重组载体转化线虫秀丽线虫。在特定缺失的情况下，GES-1在咽部的肌肉细胞(属于肠道的姐妹血统)或体壁肌肉和皮下细胞(属于肠道的近亲血统)中表达，而不是像正常情况下在肠道中的表达。这些观察结果表明，线虫肠道特异的基因表达不仅涉及肠道特异的激活子，而且还涉及存在于特定非肠道谱系的多个抑制子。
The nematode Caenorhabditis elegans was transformed with constructs containing upstream deletions of the gut-specific ges-1 carboxylesterase gene. With particular deletions, ges-1 was expressed, not as normally in the gut, but rather in muscle cells of the pharynx (which belong to a sister lineage of the gut) or in body wall muscle and hypodermal cells (which belong to a cousin lineage of the gut). These observations suggest that gut-specific gene expression in C. elegans involves not only gut-specific activators but also multiple repressors that are present in particular nongut lineages.