Regulation of germ cell function by SUMOylation.
Regulation of germ cell function by SUMOylation.
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DOI：
10.1007/s00441-015-2286-5
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发表时间：
2016-01
影响因子：
3.6
通讯作者：
Pangas SA
中科院分区：
文献类型：
--
作者：
Rodriguez A;Pangas SA
卵子发生和精子发生是严格调控的复杂过程，对生育功能至关重要。生殖细胞经过减数分裂，产生生殖所需的单倍体细胞。减数分裂中的错误，包括染色体异常的产生，可能会导致生殖缺陷和不育。减数分裂蛋白受翻译后修饰的调节，包括SUMO化，即小泛素样修饰物(SUMO)蛋白的共价连接。在这里，我们回顾了相扑蛋白在控制生殖细胞发育和成熟中的作用，基于最近在小鼠模型中的发现。一些研究已经确定了相扑蛋白在男性和女性生殖细胞中的定位。然而，更深入地了解SUMO化如何调节在卵子发生和精子发生中起关键作用的蛋白质，将有助于深入了解生殖细胞发育和生育的潜在机制。
Oogenesis and spermatogenesis are tightly regulated complex processes that are critical for fertility function. Germ cells undergo meiosis to generate haploid cells necessary for reproduction. Errors in meiosis, including the generation of chromosomal abnormalities, can result in reproductive defects and infertility. Meiotic proteins are regulated by post-translational modifications including SUMOylation, the covalent attachment of small ubiquitin-like modifier (SUMO) proteins. Here, we review the role of SUMO proteins in controlling germ cell development and maturation based on recent findings from mouse models. Several studies have characterized the localization of SUMO proteins in male and female germ cells. However, a deeper understanding of how SUMOylation regulates proteins with essential roles in oogenesis and spermatogenesis will provide useful insight into the underlying mechanisms of germ cell development and fertility.