Embryotoxicity and teratogenicity studies of an ayurvedic contraceptive - pippaliyadi vati
Embryotoxicity and teratogenicity studies of an ayurvedic contraceptive - pippaliyadi vati
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DOI：
10.1016/s0378-8741(00)00354-8
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发表时间：
2001-02-01
影响因子：
5.4
通讯作者：
Mishra, S
中科院分区：
文献类型：
--
作者：
Chaudhury, MR;Chandrasekaran, R;Mishra, S
将一种阿育吠陀避孕药 - pippaliyadi vati，含有等份的粉状种子或余甘子浆果、荜荠果和硼砂粉，口服喂给两组怀孕大鼠：一组为 2.5 倍，另一组为 5 次；人类推荐剂量。用 pippaliyadi 喂养的母亲的胎儿出生体重低且身长较小。母亲在怀孕期间体重增加较少。分析软组织和骨骼的发育缺陷。服用 pippaliyadi 的母亲的胎儿曾出现肠疝入脐带的情况。对照组和阿拉伯树胶组没有表现出这种突出。 (C) 2001 年，爱思唯尔科学爱尔兰有限公司出版。
An ayurvedic contraceptive - pippaliyadi vati, containing equal parts of powdered seeds or fruit berries of Embelia ribes, fruit of Piper longum and borax powder was fed orally to two groups of pregnant rats: 2.5 times to one and five times to the other; the recommended dose for humans. The foetuses of mothers fed with pippaliyadi had low birth weights and were smaller in length. The mothers gained less weight during gestation. Developmental defects of soft tissues and skeletons were analyzed. There were instances of herniation of the intestines into the umbilical cord in foetuses of mothers who were administered pippaliyadi. The control and the gum acacia groups did not show such herniation. (C) 2001 Published by Elsevier Science Ireland Ltd.