Hydrogel Patterning with Catechol Enables Networked Electron Flow
Hydrogel Patterning with Catechol Enables Networked Electron Flow
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DOI：
10.1002/adfm.202007709
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发表时间：
2021-01
影响因子：
19
通讯作者：
Si Wu;Zhiling Zhao;J. Rzasa;Eunkyoung Kim;Jinyang Li;Eric VanArsdale;W. Bentley;Xiaowen Shi;G. Payne
中科院分区：
文献类型：
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作者：
Si Wu;Zhiling Zhao;J. Rzasa;Eunkyoung Kim;Jinyang Li;Eric VanArsdale;W. Bentley;Xiaowen Shi;G. Payne
还原-氧化（氧化还原）反应为生物通讯提供了一种独特的模式，与更熟悉的基于离子的电模式有着根本的不同。生物学使用这两种模式通过不同的系统（免疫与神经）进行通信，并使用不同的机制来控制电荷载体的流动：可溶性离子的流动是使用结构屏障（即，膜）和门（例如，跨膜蛋白通道），而不溶性电子的流动是使用氧化还原反应网络控制的。在这里，一个简单的电化学方法来图案儿茶酚到一个灵活的多糖水凝胶的报告，它表明，图案儿茶酚区域作为节点介导的电子流通过氧化还原反应。通过该节点的电子流涉及二元氧化还原状态（氧化和还原）的切换，并且可以检测该节点的氧化还原状态（即，通过被动地观察其吸光度，或通过电化学主动地切换其氧化还原状态，来读取（“读取”）。此外，该儿茶酚节点可以通过生物机制进行切换，并且这使得所制造的儿茶酚节点能够嵌入生物化学氧化还原反应网络中，以促进生物电子通信的跨越。因此，可以设想，儿茶酚可以作为晶体管的分子等效物出现，用于可组装，可部署和可持续的氧化还原连接生物电子学。
Reduction–oxidation (redox) reactions provide a distinct modality for biological communication that is fundamentally different from the more‐familiar ion‐based electrical modality. Biology uses these two modalities for communication through different systems (immune versus nervous), and uses different mechanisms to control the flow of the charge carriers: the flow of soluble ions is controlled using structural barriers (i.e., membranes) and gates (e.g., membrane‐spanning protein channels), while the flow of insoluble electrons is controlled using redox‐reaction networks. Here, a simple electrochemical approach to pattern catechols onto a flexible polysaccharide hydrogel is reported and it is demonstrated that the patterned catechol regions serve as nodes for the mediated flow of electrons through redox reactions. Electron flow through this node involves the switching of binary redox states (oxidized and reduced) and this node's redox state can be detected (i.e., “read”) by passively observing its optical absorbance, or actively switching its redox‐state electrochemically. Further, this catechol node can be switched through biological mechanisms, and this enables the fabricated catechol node to be embedded within biochemical redox reaction networks to facilitate the spanning of bio‐electronic communication. Thus, it is envisioned that catechols can emerge as a molecular equivalent to a transistor for miniaturize‐able, deployable and sustainable redox‐linked bioelectronics.