Roles of continuous neurogenesis in the structural and functional integrity of the adult forebrain
Roles of continuous neurogenesis in the structural and functional integrity of the adult forebrain
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DOI：
10.1038/nn.2185
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发表时间：
2008-10-01
影响因子：
25
通讯作者：
Kageyama, Ryoichiro
中科院分区：
文献类型：
--
作者：
Imayoshi, Itaru;Sakamoto, Masayuki;Kageyama, Ryoichiro
神经发生在成年哺乳动物的前脑中持续发生，但成年神经发生的功能重要性仍不清楚。在这里，使用成年小鼠的遗传标记方法，我们发现持续的神经再生导致嗅球中的大多数颗粒神经元被替换，并在海马齿状回中大量增加颗粒神经元。基因消融成年小鼠新形成的神经元导致嗅球中颗粒细胞的数量逐渐减少，齿状回中颗粒细胞数量的增加受到抑制，以及已知依赖于海马体的上下文和空间记忆行为的损害。这些结果表明，嗅球整个中间神经元系统的维持和重组、齿状回现有神经元回路的调制和完善以及参与海马依赖记忆的正常行为都需要持续的神经发生。
Neurogenesis occurs continuously in the forebrain of adult mammals, but the functional importance of adult neurogenesis is still unclear. Here, using a genetic labeling method in adult mice, we found that continuous neurogenesis results in the replacement of the majority of granule neurons in the olfactory bulb and a substantial addition of granule neurons to the hippocampal dentate gyrus. Genetic ablation of newly formed neurons in adult mice led to a gradual decrease in the number of granule cells in the olfactory bulb, inhibition of increases in the granule cell number in the dentate gyrus and impairment of behaviors in contextual and spatial memory, which are known to depend on hippocampus. These results suggest that continuous neurogenesis is required for the maintenance and reorganization of the whole interneuron system in the olfactory bulb, the modulation and refinement of the existing neuronal circuits in the dentate gyrus and the normal behaviors involved in hippocampal-dependent memory.