The Field Representation Language
The Field Representation Language
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DOI：
10.1016/j.jbi.2007.03.001
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发表时间：
2008-02-01
影响因子：
4.5
通讯作者：
Tsafnat, Guy
中科院分区：
文献类型：
--
作者：
Tsafnat, Guy
定量生物医学模型的复杂性及其发布速度正在增加，如果没有自动化，管理信息几乎是不可能的。国际上正在努力为代表各种生理系统的一些数学实体提供表示语言。本文介绍了字段表示语言（FRL），一个便携式的表示值，改变了空间和/或时间。FRL是一种可扩展标记语言（XML）衍生物，支持分层数据格式版本5（HDF 5）中的大型数字数据集。FRL的组件可以通过统一资源标识符（URI）重用，URI指向外部资源，如自定义基函数，边界几何和数值数据。为了证明使用FRL作为交换，我们提出了三个模型，研究热疗癌症治疗：肝肿瘤微血管的分形模型;概率模型模拟整个磁性微球的沉积;和热疗的有限元模型。微球分布场被用来计算肿瘤周围的生热率场。我们使用FRL将微球模拟的结果传达给治疗模型。FRL促进了坐标系的转换，并近似了微球沉积场区域上的积分。(C)2007年爱思唯尔公司All rights reserved.
The complexity of quantitative biomedical models, and the rate at which they are published, is increasing to a point where managing the information has become all but impossible without automation. International efforts are underway to standardise representation languages for a number of mathematical entities that represent a wide variety of physiological systems. This paper presents the Field Representation Language (FRL), a portable representation of values that change over space and/or time. FRL is an extensible mark-up language (XML) derivative with support for large numeric data sets in Hierarchical Data Format version 5 (HDF5). Components of FRL can be reused through unified resource identifiers (URI) that point to external resources such as custom basis functions, boundary geometries and numerical data. To demonstrate the use of FRL as an interchange we present three models that study hyperthermia cancer treatment: a fractal model of liver tumour microvasculature; a probabilistic model simulating the deposition of magnetic microspheres throughout it; and a finite element model of hyperthermic treatment. The microsphere distribution field was used to compute the heat generation rate field around the tumour. We used FRL to convey results from the microsphere simulation to the treatment model. FRL facilitated the conversion of the coordinate systems and approximated the integral over regions of the microsphere deposition field. (C) 2007 Elsevier Inc. All rights reserved.