Differential contributions of the basolateral and central amygdala in the acquisition and expression of conditioned relapse to cocaine-seeking behavior
Differential contributions of the basolateral and central amygdala in the acquisition and expression of conditioned relapse to cocaine-seeking behavior
复制标题
DOI：
10.1523/jneurosci.21-14-j0002.2001
复制
发表时间：
2001-07-15
影响因子：
5.3
通讯作者：
See, RE
中科院分区：
文献类型：
--
作者：
Kruzich, PJ;See, RE
杏仁核被认为是厌恶性和食欲性条件反射中情绪学习的重要中介。在这里，我们第一次展示了杏仁核不同的亚区在复发模型中通过药物配对线索维持的可卡因寻找行为的获得和表达中发挥独特的作用。用钠通道阻滞剂河豚毒素可逆地失活基底外侧杏仁核，破坏了药物对刺激维持的条件性增强效应的获得和表达。然而，中央杏仁核的失活只扰乱了药物配对刺激的条件性强化效应的表达，而不是获得。我们的结果表明，这些核团参与杏仁核回路的组成部分，以驱动刺激强化联想产生的可卡因寻找行为。
The amygdala is known to be a critical mediator of emotional learning in aversive and appetitive conditioning. Here we show for the first time that distinct subregions of the amygdala play unique roles in the acquisition and expression of cocaine-seeking behavior maintained by drug-paired cues in a model of relapse. Reversible inactivation of the basolateral amygdala with the sodium channel blocker tetrodotoxin disrupted both the acquisition and expression of the conditioned reinforcing effects maintained by drug-paired stimuli. However, inactivation of the central amygdala disrupted only the expression, but not the acquisition, of the conditioned reinforcing effects of drug-paired stimuli. Our results demonstrate that these nuclei participate as components of an amygdalar circuit to drive cocaine-seeking behavior produced by stimulus-reinforcement associations.