Neuroblastoma with orbital metastasis: ophthalmic presentation and role of ophthalmologists
Neuroblastoma with orbital metastasis: ophthalmic presentation and role of ophthalmologists
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DOI：
10.1038/sj.eye.6701912
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发表时间：
2006-04-01
期刊：
影响因子：
3.9
通讯作者：
Simmons, IG
中科院分区：
文献类型：
--
作者：
Ahmed, S;Goel, S;Simmons, IG
神经母细胞瘤主要是一种早期儿童的肿瘤，转移到眼眶。在这种情况下，眼科医生会参与多学科管理。这一独特的系列从第三转诊中心是用来阐述眼科协会和眼科医生的作用，在这种罕见的condition.Methods的情况下，进行了审查6例谁提出的儿童眼科肿瘤联络服务在利兹教学医院在1998年和2003年之间。结果平均年龄为29.8个月（范围15 - 69个月）。平均随访时间为19.5个月（范围2 - 58个月）。一名儿童在治疗期间死亡。两人已完成治疗，正在接受随访。这六个孩子的临床表现是四个眼球突出，两个眶周瘀斑，两个眼球运动受限，一个结膜下出血。只有一例发展成盲。结论眼科医生在转移性眼眶神经母细胞瘤患者中的作用可以从一个支持性的作用，积极干预和管理眼科并发症。眼科医生参与诊断和分期，以及监测对原发性疾病和继发性眼科并发症的治疗反应。
Introduction Neuroblastoma is predominantly a tumour of early childhood, which metastasises to the orbits. In such cases, ophthalmologists are involved in the multidisciplinary management. This unique series from a tertiary referral centre is used to elaborate the ophthalmic associations and the ophthalmologist's role in this rare condition.Methods A review of case notes was performed on six patients who presented to the paediatric ophthalmology - oncology liaison service at the Leeds teaching hospitals between 1998 and 2003. The ophthalmic outcome and role of the ophthalmologist were assessed.Results Average age of presentation was 29.8 months ( range 15 - 69 months). Average duration of follow-up was 19.5 months ( range 2 - 58 months). One child died during treatment. Two have completed treatment and are under follow-up. Presenting features of the six children were proptosis in four, periorbital ecchymosis in two, ocular motility restriction in two, and subconjunctival haemorrhage in one. Only one case developed blindness.Conclusions The role of the ophthalmologist in patients with metastatic orbital neuroblastoma can vary from a supportive role to one of active intervention and management of ophthalmic complications. The ophthalmologist is involved in diagnosis and staging as well as monitoring response to treatment of both the primary disease and secondary ophthalmic complications.