Human YRNA 4 (HY4) plasma levels are a prognostic indicator of SARS-CoV-2 infection clinical severity.
Human YRNA 4 (HY4) plasma levels are a prognostic indicator of SARS-CoV-2 infection clinical severity.
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DOI：
10.17912/micropub.biology.000925
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发表时间：
2023
影响因子：
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通讯作者：
Borchert, Glen M
中科院分区：
文献类型：
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作者：
Olliff, Nathaniel S;Hunt, Miles A;Paudel, Sunita S;Nguyen, Kevin N;Delcher, Haley A;DeMeis, Jeffrey D;Roberts, Justin T;Fouty, Brian W;Audia, Jonathon P;Kim, Jin H;Borchert, Glen M
SARS-CoV-2感染可导致从无症状/轻度疾病到严重COVID-19/死亡的一系列结果。在这项研究中，我们调查了小的非编码RNA（sncRNA）的差异表达的患者队列之间的疾病严重程度定义。我们收集了血浆样本，根据临床结果对这些样本进行分层，并对其循环sncRNA进行测序。令人兴奋的是，我们发现YRNA HY 4在经历轻度和重度疾病的患者之间显示出显著的差异表达（p=0.025）。与最近鉴定血浆YRNA作为流感感染严重程度的指标的报道一致，我们的结果强烈表明循环HY 4水平代表可能的SARS-CoV-2患者感染结果的强有力的预后指标。
SARS-CoV-2 infection can result in a range of outcomes from asymptomatic/mild disease to severe COVID-19/fatality. In this study, we investigated the differential expression of small noncoding RNAs (sncRNAs) between patient cohorts defined by disease severity. We collected plasma samples, stratified these based on clinical outcomes, and sequenced their circulating sncRNAs. Excitingly, we found YRNA HY4 displays significant differential expression (p=0.025) between patients experiencing mild and severe disease. In agreement with recent reports identifying plasma YRNAs as indicators of influenza infection severity, our results strongly suggest that circulating HY4 levels represent a powerful prognostic indicator of likely SARS-CoV-2 patient infection outcome.