Rfam 12.0: updates to the RNA families database.
Rfam 12.0: updates to the RNA families database.
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DOI:
10.1093/nar/gku1063
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发表时间:
2015-01
影响因子:
14.9
通讯作者:
Finn RD
中科院分区:
文献类型:
--
作者:
Nawrocki EP;Burge SW;Bateman A;Daub J;Eberhardt RY;Eddy SR;Floden EW;Gardner PP;Jones TA;Tate J;Finn RD
The Rfam database (available at http://rfam.xfam.org) is a collection of non-coding RNA families represented by manually curated sequence alignments, consensus secondary structures and annotation gathered from corresponding Wikipedia, taxonomy and ontology resources. In this article, we detail updates and improvements to the Rfam data and website for the Rfam 12.0 release. We describe the upgrade of our search pipeline to use Infernal 1.1 and demonstrate its improved homology detection ability by comparison with the previous version. The new pipeline is easier for users to apply to their own data sets, and we illustrate its ability to annotate RNAs in genomic and metagenomic data sets of various sizes. Rfam has been expanded to include 260 new families, including the well-studied large subunit ribosomal RNA family, and for the first time includes information on short sequence- and structure-based RNA motifs present within families.
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DOI:
10.1093/bioinformatics/btt509
发表时间:
2013-11-15
期刊:
Bioinformatics (Oxford, England)
影响因子:
--
作者:
Nawrocki EP;Eddy SR
通讯作者:
Eddy SR
影响因子:
14.9
作者:
Flicek P;Amode MR;Barrell D;Beal K;Billis K;Brent S;Carvalho-Silva D;Clapham P;Coates G;Fitzgerald S;Gil L;Girón CG;Gordon L;Hourlier T;Hunt S;Johnson N;Juettemann T;Kähäri AK;Keenan S;Kulesha E;Martin FJ;Maurel T;McLaren WM;Murphy DN;Nag R;Overduin B;Pignatelli M;Pritchard B;Pritchard E;Riat HS;Ruffier M;Sheppard D;Taylor K;Thormann A;Trevanion SJ;Vullo A;Wilder SP;Wilson M;Zadissa A;Aken BL;Birney E;Cunningham F;Harrow J;Herrero J;Hubbard TJ;Kinsella R;Muffato M;Parker A;Spudich G;Yates A;Zerbino DR;Searle SM
通讯作者:
Searle SM
影响因子:
4.4
作者:
Anthon C;Tafer H;Havgaard JH;Thomsen B;Hedegaard J;Seemann SE;Pundhir S;Kehr S;Bartschat S;Nielsen M;Nielsen RO;Fredholm M;Stadler PF;Gorodkin J
通讯作者:
Gorodkin J
影响因子:
4.8
作者:
Liu, MY;Gui, GJ;Romeo, T
通讯作者:
Romeo, T
影响因子:
14.9
作者:
Pichon, Christophe;du Merle, Laurence;Le Bouguenec, Chantal
通讯作者:
Le Bouguenec, Chantal