Immune dysfunction associated with graft-versus-host reaction in mice transplanted across minor histocompatibility barriers. I. Depressed antigen-specific antibody responses to bacteriophage phi chi 174.
Immune dysfunction associated with graft-versus-host reaction in mice transplanted across minor histocompatibility barriers. I. Depressed antigen-specific antibody responses to bacteriophage phi chi 174.
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跨越较小组织相容性障碍移植的小鼠中与移植物抗宿主反应相关的免疫功能障碍。
DOI：
10.1097/00007890-198906000-00029
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发表时间：
1989
期刊：
影响因子：
6.2
通讯作者：
Ochs,HD
中科院分区：
文献类型：
--
作者：
Hamilton,BL;Ochs,HD
在四种小鼠中研究了移植物抗宿主反应对次要组织相容性抗原的反应对t依赖性抗原抗体反应的影响。经致死性照射的小鼠被移植骨髓加上h -2相容供体的脾脏细胞。同基因骨髓移植受者和同种异体骨髓移植受者在骨髓移植后第28天（原发性）和第56天（继发性）免疫时，对噬菌体o [chi] 174的抗体反应正常。异体骨髓+脾细胞受体仅产生少量特异性抗体，二次免疫后不能产生IgG抗体。抑制抗体反应的模式表明，小抗原GVHR小鼠免疫功能障碍的主要机制是缺乏T辅助细胞功能。
The effect of the graft-versus-host reaction in response to minor histocompatibility antigens on the antibody response to a T-dependent antigen was studied in four strains of mice. Lethally irradiated mice were transplanted with bone marrow plus graded numbers of spleen cells from H-2-compatible donors. Recipients of syngeneic bone marrow transplants and recipients of allogeneic bone marrow depleted of T cells made normal antibody responses to bacteriophage o [chi] 174 when immunized on day 28 (primary) and day 56 (secondary) after marrow transplantation. Recipients of allogeneic bone marrow plus spleen cells made only small amounts of specific antibody and failed to make IgG antibody after secondary immunization. The pattern of the depressed antibody response suggests that the primary mechanism of immune dysfunction in mice with the minor antigen GVHR is a lack of T helper cell function.