Nucleus accumbens opioids regulate flavor-based preferences in food consumption
Nucleus accumbens opioids regulate flavor-based preferences in food consumption
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DOI：
10.1016/j.neuroscience.2006.06.067
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发表时间：
2006-11
期刊：
影响因子：
3.3
通讯作者：
J. Woolley;B. Lee;H. Fields
中科院分区：
文献类型：
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作者：
J. Woolley;B. Lee;H. Fields
阿片样物质信号在丘脑核（NAcc）调节摄食行为，具有特别强烈的影响，对高适口性食物的消费。由于大量营养素含量可能有助于适口性，因此不确定阿片类药物对食物消费的调节主要是基于其大量营养素含量还是其风味本身。为了分离风味的影响，我们操纵了大鼠NAcc中的阿片信号传导，并量化了不同风味但营养相同的颗粒的消耗。当单独提供任一风味的颗粒时，向NAcc中微量注射d-Ala 2，N，Me-Phe 4，Gly-ol 5-脑啡肽（DAMGO（μ阿片受体（MOP）激动剂））同样增加两种风味的颗粒的消耗。然而，当两种口味的颗粒同时存在时，NAcc中的DAMGO选择性地增加，而NAcc中的纳洛酮（一种非选择性阿片类拮抗剂）选择性地减少，消耗更优选的口味。全身注射纳洛酮没有风味特异性影响，减少两种风味的消耗量相同。通过局部微量注射蝇蕈醇（GABAA激动剂）非选择性灭活NAcc神经元，增加了更多和更少偏好的口味的消费。这些结果表明，阿片样物质信号直接调节NAcc神经元的一个子集，该神经元可以选择性地增强仅基于风味线索的优选可口食物的消费。
Opioid signaling in the nucleus accumbens (NAcc) regulates feeding behavior, having particularly strong effects on consumption of highly palatable foods. Since macronutrient content may contribute to palatability, it is uncertain whether opioid regulation of food consumption is based primarily on its macronutrient content or its flavor per se. In order to isolate the effect of flavor, we manipulated opioid signaling in the NAcc in rats and quantified consumption of differently flavored but nutritionally identical pellets. When pellets of either flavor were presented alone, microinjection of d-Ala2,N,Me-Phe4,Gly-ol5-enkephalin (DAMGO (a μ opioid receptor (MOP) agonist)) into the NAcc increased consumption of pellets of both flavors equally. When both flavors of pellets were presented simultaneously, however, DAMGO in the NAcc selectively increased, while naltrexone (a non-selective opioid antagonist) in the NAcc selectively decreased, consumption of the more preferred flavor. Systemic naltrexone injection had no flavor specific effects, decreasing consumption of both flavors equally. Non-selective inactivation of NAcc neurons by local microinjection of muscimol (a GABAAagonist) increased consumption of both the more- and less-preferred flavors equally. These results indicate that opioid signaling directly regulates a subset of NAcc neurons that can selectively enhance consumption of preferred palatable foods based exclusively on flavor cues.