Suspension of deformable particles in Newtonian and viscoelastic fluids in a microchannel
Suspension of deformable particles in Newtonian and viscoelastic fluids in a microchannel
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DOI：
10.1007/s10404-018-2182-x
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发表时间：
2019-01
影响因子：
2.8
通讯作者：
A. Raffiee;S. Dabiri;A. Ardekani
中科院分区：
文献类型：
--
作者：
A. Raffiee;S. Dabiri;A. Ardekani
在本文中，我们研究了在一个中等体积分数的细胞悬浮液中流动的微通道中充满牛顿或粘弹性流体和细胞的大小，细胞的体积分数，惯性，变形能力，和流体弹性的细胞分布的作用进行调查。我们的结果表明，使用恒定粘度的粘弹流体将细胞推向通道中心线，这可用于细胞聚焦的微流体装置，例如细胞计数器。无细胞层增加，这为微流体装置中分离稀有细胞提供了更大的间隙。此外，我们表明，体积流量可以显着提高与添加聚合物的悬浮液。这种效应提高了处理速度，这在设计微流体装置中是有意义的。这一基础研究可以提供对流体的流变学性质的作用的见解，可以调节流体以控制细胞的运动，从而有效地设计微流体装置。
In this paper, we study a suspension of cells at a moderate volume fraction flowing in a microchannel filled with Newtonian or viscoelastic fluids and investigate the role of cell size, cell volume fraction, inertia, deformability, and fluid elasticity on the cell distribution. Our results suggest that the use of constant-viscosity viscoelastic fluid pushes the cells toward the channel centerline which can be used in microfluidic devices used for cell focusing such as cytometers. The cell-free layer increases which provides larger gap for separating rare cells in microfluidic devices. Furthermore, we show that the volumetric flow rate can be significantly enhanced with the addition of polymers in the suspending fluid. This effect enhances the processing speed which is of interest in designing microfluidic devices. This fundamental study can provide insight on the role of rheological properties of the fluid that can be tuned to control the motion of the cells for efficient design of microfluidic devices.