Polycationic Synergistic Antibacterial Agents with Multiple Functional Components for Efficient Anti-Infective Therapy
Polycationic Synergistic Antibacterial Agents with Multiple Functional Components for Efficient Anti-Infective Therapy
复制标题
具有多种功能成分的聚阳离子协同抗菌剂，用于高效抗感染治疗
DOI：
10.1002/adfm.201706709
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发表时间：
2018-04-05
影响因子：
19
通讯作者：
Xu, Fu-Jian
中科院分区：
文献类型：
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作者：
Zhu, Yiwen;Xu, Chen;Xu, Fu-Jian
多功能抗菌光动力疗法是对抗常规耐药菌和多重耐药菌的一种很有前途的方法。在这项工作中，曙红Y(EY)基抗菌多阳离子(EY-QEGED-R，R=-CH3或-C6H13)通过简单的开环反应很容易地合成了具有多种功能成分的季铵盐、光敏剂、伯胺和羟基物种。在光照射下，这种抗菌聚合物对大肠杆菌和金黄色葡萄球菌都表现出很高的抗菌效率。特别是，EY-QEGED-R由于结合了光动力学和季铵盐的抗菌作用而产生了显著的协同抗菌活性。由于其丰富的伯胺基团，EY-QEGED-R也可以很容易地通过聚多巴胺粘合层被涂覆在不同的基材上，如玻璃片和无纺布。得到的EY-QEGED-CH3(S-EY-QEGED-CH3)表面涂层具有良好的体外抗菌效果。大量的羟基赋予S-EY-QEGED-CH3潜在的对死亡细菌的防污能力。抗菌聚合物涂层还表现出低细胞毒性和良好的血液相容性。更重要的是，S-EY-QEGED-CH3显著增强了对感染大鼠模型的体内治疗效果。本工作为合理设计高性能抗菌材料对抗生物医疗器械相关感染提供了一种有效的策略。
Multifunctional antibacterial photodynamic therapy is a promising method to combat regular and multidrug-resistant bacteria. In this work, eosin Y (EY)-based antibacterial polycations (EY-QEGED-R, R = -CH3 or -C6H13) with versatile types of functional components including quaternary ammonium, photosensitizer, primary amine, and hydroxyl species are readily synthesized based on simple ring-opening reactions. In the presence of light irradiation, such antibacterial polymers exhibit high antibacterial efficiency against both Escherichia coli and Staphylococcus aureus. In particular, EY-QEGED-R elicits a remarkable synergistic antibacterial activity owing to the combined photodynamic and quaternary ammonium antibacterial effects. Due to its rich primary amine groups, EY-QEGED-R also can be readily coated on different substrates, such as glass slides and nonwoven fabrics via an adhesive layer of polydopamine. The resultant surface coating of EY-QEGED-CH3 (s-EY-QEGED-CH3) produces excellent in vitro antibacterial efficacy. The plentiful hydroxyl groups impart s-EY-QEGED-CH3 with potential antifouling capability against dead bacteria. The antibacterial polymer coatings also demonstrate low cytotoxicity and good hemocompatibility. More importantly, s-EY-QEGED-CH3 significantly enhances in vivo therapeutic effects on an infected rat model. The present work provides an efficient strategy for the rational design of high-performance antibacterial materials to fight biomedical device-associated infections.