Blood Plasma Derivatives for Tissue Engineering and Regenerative Medicine Therapies.
Blood Plasma Derivatives for Tissue Engineering and Regenerative Medicine Therapies.
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DOI：
10.1089/ten.teb.2018.0008
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发表时间：
2018-12
期刊：
影响因子：
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通讯作者：
Mano JFCDL
中科院分区：
文献类型：
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作者：
Santos SCNDS;Sigurjonsson ÓE;Custódio CA;Mano JFCDL
富血小板血浆（PRP）及其衍生物在再生医学中得到了广泛的研究和应用。使用PRP作为细胞培养基的补充一直显示增强干细胞增殖，迁移和分化。此外，有证据表明，PRP含有有助于再生过程的高浓度生长因子和蛋白质，这支持了PRP的临床应用。基于PRP的治疗具有成本效益，并且受益于使用患者自身生长因子的可及性和安全性。近年来，基于PRP的生物材料在结构和功能上都有了很大的发展。在这里，我们概述了最相关的PRP应用，包括PRP基材料在组织工程和再生医学中的应用。综述了组织工程和再生医学领域面临的挑战，并对未来的发展方向进行了展望。
Platelet-rich plasma (PRP) and its derivatives have been investigated and applied in regenerative medicine. The use of PRP as a supplement of cell culture media has consistently shown to potentiate stem cell proliferation, migration, and differentiation. In addition, the clinical utility of PRP is supported by evidence that PRP contains high concentrations of growth factors and proteins which contribute to the regenerative process. PRP based therapies are cost effective and also benefit from the accessibility and safety of using the patient's own growth factors. In the last years, it has been witnessed a great development on PRP based biomaterials, with both structural and functional purposes. Here we overview the most relevant PRP applications encompassing PRP based materials for tissue engineering and regenerative medicine. This review also summarizes the challenges in the fields of tissue engineering and regenerative medicine and provides a perspective on future directions.