NOTCH4 gene promoter polymorphism is associated with the age of onset in schizophrenia
NOTCH4 gene promoter polymorphism is associated with the age of onset in schizophrenia
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DOI：
10.1097/01.ypg.0000056681.82896.6b
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发表时间：
2003-06-01
影响因子：
0.9
通讯作者：
Leinonen, E
中科院分区：
文献类型：
--
作者：
Anttila, S;Kampman, O;Leinonen, E
目的NOTCH 4基因启动子区-25位点多态性导致TT、CT和CC三种基因型。这些被认为是精神分裂症的一个新的独立遗传危险因素。为探讨NOTCH 4基因T-25 C多态性与精神分裂症相关因素的关系，采用前瞻性病例对照研究方法，对94例精神分裂症患者和94例健康献血员进行了NOTCH 4基因启动子T-25 C多态性检测。Kaplan-Meier对数秩检验P
Objectives The NOTCH4 gene has a promoter polymorphism at position - 25, which leads to the three genotypes TT, CT and CC. These have been suggested to present a novel independent genetic risk factor for schizophrenia. We conducted a prospective case-control study to explore the impact of NOTCH4 T-25C polymorphism on the factors associated with schizophrenia.Method NOTCH4 gene promoter T-25C polymorphism was determined by polymerase chain reaction among 94 patients with schizophrenia and 94 healthy age-matched and sex-matched blood donors.Results The T allele was highly associated with an earlier age of onset in male patients of schizophrenia (Kaplan-Meier log-rank test P