Episodic sequence memory is supported by a theta-gamma phase code.
Episodic sequence memory is supported by a theta-gamma phase code.
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我们从经验中获得的意义并不是对元素的简单静态提取，而是很大程度上基于这些元素发生的顺序。模型提出，序列编码由高频振荡和低频振荡之间的相互作用支持，使得体验中的元素由以较高频率（即伽马）发射的神经细胞组件来表示，而顺序顺序则由相对于较低频率振荡（即西塔）的特定发射时间进行编码。在人类情景序列记忆形成过程中，我们提供的证据表明，不同序列位置的项目沿着 theta 振荡的不同阶段表现出相对较大的伽马功率。此外，这种分离与成功的时间顺序记忆有关。这些结果提供了令人信服的证据，表明顺序记忆（情景记忆的核心组成部分）利用了普遍存在的θ-γ相位-幅度耦合的生理机制。
The meaning we derive from our experiences is not a simple static extraction of the elements, but is largely based on the order in which those elements occur. Models propose that sequence encoding is supported by interactions between high and low frequency oscillations, such that elements within an experience are represented by neural cell assemblies firing at higher frequencies (i.e. gamma) and sequential order is coded by the specific timing of firing with respect to a lower frequency oscillation (i.e. theta). During episodic sequence memory formation in humans, we provide evidence that items in different sequence positions exhibit relatively greater gamma power along distinct phases of a theta oscillation. Furthermore, this segregation is related to successful temporal order memory. These results provide compelling evidence that memory for order, a core component of an episodic memory, capitalizes on the ubiquitous physiological mechanism of theta-gamma phase-amplitude coupling.