A Two-Dimensional Biodegradable Niobium Carbide (MXene) for Photothermal Tumor Eradication in NIR-I and NIR-II Biowindows
A Two-Dimensional Biodegradable Niobium Carbide (MXene) for Photothermal Tumor Eradication in NIR-I and NIR-II Biowindows
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DOI：
10.1021/jacs.7b07818
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发表时间：
2017-11-15
影响因子：
15
通讯作者：
Shi, Jianlin
中科院分区：
文献类型：
--
作者：
Lin, Han;Gao, Shanshan;Shi, Jianlin
传统上，高温固相反应和烧结制备的陶瓷基材料，由于其可调节的生物相容性和机械性能，是硬组织工程中首选的骨支架材料。然而，它们可能的生物医学应用很少被考虑，特别是在第一和第二近红外光（NIR-I和NIR-II）生物窗口中的癌症光治疗应用。在这项工作中，据我们所知，我们首次探索了一种新型的2D碳化铌（Nb2C）， MXene，在NIR-I和NIR-II窗口中对小鼠肿瘤异种移植物进行高效的体内光热消融。采用两步液体剥离法，结合逐级分层和插层工艺，制备了二维Nb2C纳米片。超薄的横向纳米Nb2C NSs表现出极高的光热转换效率（在NIR-I下为36.4%，在NIR-II下为45.65%）和较高的光热稳定性。Nb2C NSs具有对人髓过氧化物酶的生物降解性，低光毒性和高生物相容性。特别是，这些表面工程的Nb2C NSs在NIR-I和NIR-II生物窗口中都具有高效的体内光热消融和肿瘤根除作用。本工作通过合理设计二维MXenes的组成，探索其相关的理化性质，特别是在癌症光疗方面的应用前景，显著拓宽了二维MXenes的应用前景。
Conventionally, ceramics-based materials, fabricated by high-temperature solid-phase reaction and sintering, are preferred as bone scaffolds in hard-tissue engineering because of their tunable biocompatibility and mechanical properties. However, their possible biomedical applications have rarely been considered, especially the cancer photo therapeutic applications in both the first and second near infrared light (NIR-I and NIR-II) biowindows. In this work, we explore, for the first time as far as we know, a novel kind of 2D niobium carbide (Nb2C), MXene, with highly efficient in vivo photothermal ablation of mouse tumor xenografts in both NIR-I and NIR-II windows. The 2D Nb2C nanosheets (NSs) were fabricated by a facile and scalable two-step liquid exfoliation method combining stepwise delamination and intercalation procedures. The ultrathin, lateral-nanosized Nb2C NSs exhibited extraordinarily high photothermal conversion efficiency (36.4% at NIR-I and 45.65% at NIR-II), as well as high photothermal stability. The Nb2C NSs intrinsically feature unique enzyme-responsive biodegradability to human myeloperoxidase, low phototoxicity, and high biocompatibility. Especially, these surface-engineered Nb2C NSs present highly efficient in vivo photothermal ablation and eradication of tumor in both NIR-I and NIR-II biowindows. This work significantly broadens the application prospects of 2D MXenes by rationally designing their compositions and exploring related physiochemical properties, especially on phototherapy of cancer.