Marked effect of DNA on collagen fibrillogenesis in vitro.
Marked effect of DNA on collagen fibrillogenesis in vitro.
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DNA 对体外胶原纤维形成的显着影响。
DOI：
10.1016/s0141-8130(97)00021-4
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发表时间：
1997
影响因子：
8.2
通讯作者：
N. Nishi
中科院分区：
文献类型：
--
作者：
H. Kitamura;Chiaki Iwamoto;N. Sakairi;S. Tokura;N. Nishi
在 DNA 存在的情况下，胶原原纤维的生长比在 DNA 不存在的情况下生长得更快。在 DNA 存在的情况下形成的一些胶原原纤维比在 DNA 不存在的情况下形成的胶原原纤维明显更宽。此外，尽管使用胃蛋白酶消化的胶原蛋白，交叉带也非常明显。这些结果表明 DNA 不仅吸附到胶原蛋白上，而且还诱导胶原蛋白异常的原纤维形成。
Growth of collagen fibrils in the presence of DNA was more rapid than that in the absence of DNA. Some of collagen fibrils formed in the presence of DNA were significantly wider than those in the absence of DNA. Moreover, the cross-bandings were also very distinct in spite of using pepsin-digested collagen. These results suggest that DNA not only adsorbs to collagen but induces the extraordinary fibrillogenesis of collagen.