Shaping Nanoparticles with Hydrophilic Compositions and Hydrophobic Properties as Nanocarriers for Antibiotic Delivery.
Shaping Nanoparticles with Hydrophilic Compositions and Hydrophobic Properties as Nanocarriers for Antibiotic Delivery.
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DOI：
10.1021/acscentsci.5b00199
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发表时间：
2015-09-23
影响因子：
18.2
通讯作者：
Yu C
中科院分区：
文献类型：
--
作者：
Ahmad Nor Y;Niu Y;Karmakar S;Zhou L;Xu C;Zhang J;Zhang H;Yu M;Mahony D;Mitter N;Cooper MA;Yu C
受自然界中莲花效应的启发，表面粗糙度工程在许多领域中产生了新的材料和应用。尽管在超疏水和超疏油材料方面取得了快速进展，但这种大自然选择的概念尚未应用于设计用于药物递送的先进纳米载体。具有粗糙表面的纳米颗粒用于基因递送的开发已经出现了开创性的工作;然而，采用表面拓扑工程制备具有亲水性组合物但在纳米级水平具有增强的疏水性的纳米颗粒仍然是一个挑战。在这里，我们报告的第一次的独特性质的介孔空心二氧化硅（MHS）纳米球与控制表面粗糙度。与具有光滑表面的MHS相比，具有相同亲水组成的粗糙介孔中空二氧化硅（RMHS）纳米颗粒显示出不寻常的疏水性，导致对一系列疏水分子的更高吸附和亲水分子的受控释放。负载万古霉素的RMHS表现出增强的抗菌作用。我们的策略提供了一个新的途径，在设计新颖的纳米载体，用于不同的生物应用。二氧化硅纳米粒子通过产生粗糙表面而具有疏水性质，显示出作为下一代纳米载体的有前途的应用，用于递送具有增强性能的抗生素。
Inspired by the lotus effect in nature, surface roughness engineering has led to novel materials and applications in many fields. Despite the rapid progress in superhydrophobic and superoleophobic materials, this concept of Mother Nature’s choice is yet to be applied in the design of advanced nanocarriers for drug delivery. Pioneering work has emerged in the development of nanoparticles with rough surfaces for gene delivery; however, the preparation of nanoparticles with hydrophilic compositions but with enhanced hydrophobic property at the nanoscale level employing surface topology engineering remains a challenge. Herein we report for the first time the unique properties of mesoporous hollow silica (MHS) nanospheres with controlled surface roughness. Compared to MHS with a smooth surface, rough mesoporous hollow silica (RMHS) nanoparticles with the same hydrophilic composition show unusual hydrophobicity, leading to higher adsorption of a range of hydrophobic molecules and controlled release of hydrophilic molecules. RMHS loaded with vancomycin exhibits an enhanced antibacterial effect. Our strategy provides a new pathway in the design of novel nanocarriers for diverse bioapplications. Silica nanoparticles were prepared with a hydrophobic nature through creating a rough surface, showing promising applications as next-generation nanocarriers for delivery of antibiotics with enhanced performance.