How protein chemists learned about the hydrophobic factor
How protein chemists learned about the hydrophobic factor
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DOI：
10.1002/pro.5560060627
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发表时间：
1997-06-01
期刊：
影响因子：
8
通讯作者：
Tanford, C
中科院分区：
文献类型：
--
作者：
Tanford, C
目前普遍认为，疏水力是导致多肽链折叠成紧凑的球状实体的主要能量因素。1938年，欧文·朗缪尔（Irving Langmuir）首次向蛋白质化学家明确介绍了这一原理，朗缪尔是过去将疏水性应用于其他问题的大师。伯纳尔。但是，这一建议和认可都是在一场关于一个完全不同的结构原则的辩论过程中提出的，即D.这很快就被证明是理论和实验上无法支持的。作为一个更具体的概念，直接用结构术语表达，环醇假说比疏水原理受到更多的关注，后者从未真正进入蛋白质科学的主流，直到1959年，当它在W. Kauzmann H. S.弗兰克和M.埃文斯本身与蛋白质折叠无关，但他在蛋白质化学家接受疏水性概念的过程中可能发挥了重要作用，因为他提供了一个粗略但切实的图像，说明疏水性本身是由水结构引起的。
It is generally accepted today that the hydrophobic force is the dominant energetic factor that leads to the folding of polypeptide chains into compact globular entities. This principle was first explicitly introduced to protein chemists in 1938 by Irving Langmuir, past master in the application of hydrophobicity to other problems, and was enthusiastically endorsed by J.D. Bernal. But both proposal and endorsement came in the course of a debate about a quite different structural principle, the so-called ''cyclol hypothesis'' proposed by D. Wrinch, which soon proved to be theoretically and experimentally unsupportable. Being a more tangible idea, directly expressed in structural terms, the cyclol hypothesis received more attention than the hydrophobic principle and the latter never actually entered the mainstream of protein science until 1959, when it was thrust into the limelight in a lucid review by W. Kauzmann. A theoretical paper by H.S. Frank and M. Evans, not itself related to protein folding, probably played a major role in the acceptance of the hydrophobicity concept by protein chemists because it provided a crude but tangible picture of the origin of hydrophobicity per se in terms of water structure.