Analysis of morphine responses in mice reveals a QTL on Chromosome 7.

Analysis of morphine responses in mice reveals a QTL on Chromosome 7.
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DOI:
10.12688/f1000research.9484.2
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发表时间:
2016
期刊:
影响因子:
--
通讯作者:
Delprato A
Delprato A
中科院分区:
其他
文献类型:
--
作者:
Crusio WE;Dhawan E;Chesler EJ;Delprato A

文献摘要

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In this study we identified a quantitative trait locus (QTL) on mouse Chromosome 7 associated with locomotor activity and rearing post morphine treatment. This QTL was revealed after correcting for the effects of another QTL peak on Chromosome 10 using composite interval mapping. The positional candidate genes are Syt9 and Ppfibp2. Several other genes within the interval are linked to neural processes, locomotor activity, and the defensive response to harmful stimuli.