Ionic-liquid matrices for improved analysis of phospholipids by MALDI-TOF mass spectrometry
Ionic-liquid matrices for improved analysis of phospholipids by MALDI-TOF mass spectrometry
复制标题
DOI：
10.1016/j.jasms.2005.01.017
复制
发表时间：
2005-05-01
影响因子：
3.2
通讯作者：
Hsu, FF
中科院分区：
文献类型：
--
作者：
Li, YL;Gross, ML;Hsu, FF
与晶体基质2，5-二羟基苯甲酸(2，5-DHB)相比，离子液体基质(ILM)用于磷脂(Pls)具有更高的信号强度、更小的斑点尺寸、改善的斑点均匀性、更好的信号重复性以及相当或更好的检测限。电离产物与含有2，5-DHB的电离产物相当，尽管使用ILM有更强的生成碱金属离子加合物的倾向和较低的即时碎裂程度。(C)2005年美国质谱学学会。
The use of ionic liquid matrices (ILMs) for phospholipids (PLs) affords higher signal intensity, smaller spot size, improved spot homogeneity, better signal reproducibility, and comparable or better detection limits compared to that of the crystalline matrix 2,5-dihydroxybenzoic acid (2,5-DHB). The ionization products are comparable to those with 2,5-DHB although the use of ILMs gives a stronger tendency to produce alkali-metal-ion adducts and a lower extent of prompt fragmentation. (c) 2005 American Society for Mass Spectrometry.