Biomonitoring California Protocol for Following up on Elevated Levels of Urinary Arsenic.
Biomonitoring California Protocol for Following up on Elevated Levels of Urinary Arsenic.
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DOI：
10.3390/ijerph20075269
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发表时间：
2023-03-27
影响因子：
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通讯作者：
Hoover, Sara
中科院分区：
文献类型：
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作者：
Iyer, Shoba;Kauffman, Duyen;Steinmaus, Craig;Hoover, Sara
目的：为尿砷水平升高，特别是无机砷水平升高的加州研究参与者制定和实施一项后续的生物监测方案。方法：选取20μg/L为尿无机砷关注水平，以总砷≥为20μg/L为形态。无机砷水平升高的参与者被告知他们的水平，并被邀请参加一项电话调查，以帮助确定可能的接触来源。我们在加州的四项生物监测研究中阐述了这一协议，这些研究收集了2010-2013年间该州各地的样本。结果：四项研究中有48名参与者的尿无机砷水平升高。食用大米和大米制品是最常见的无机砷暴露的潜在来源。结论：在48名无机砷升高的受试者中，如果我们使用先前公布的50微克/L总砷的阈值来鉴定尿样的形态，将会漏掉27名。该方案填补了临床文献中的一个空白，提供了一种更健康保护的方法来识别尿无机砷升高的个人，并帮助确定潜在的重要接触来源。
Objectives: to develop and implement a follow-up protocol for Biomonitoring California study participants with elevated levels of urinary arsenic, particularly inorganic forms. Methods: We selected 20 μg/L as the level of concern for urinary inorganic arsenic; samples with total arsenic ≥20 μg/L were speciated. Participants with elevated inorganic arsenic were notified of their level and invited to participate in a telephone survey to help determine possible exposure sources. We illustrate the protocol in four Biomonitoring California studies, which collected samples from 2010–2013 in locations across the state. Results: 48 participants in the four studies had elevated urinary inorganic arsenic levels. Consumption of rice and rice-based products was the most commonly identified potential source of inorganic arsenic exposure. Conclusions: Of 48 participants with elevated inorganic arsenic, 27 would have been missed if we had used the previously published threshold of 50 µg/L total arsenic to identify urine samples for speciation. This protocol fills a gap in the clinical literature by providing a more health-protective approach to identify individuals with elevated urinary inorganic arsenic and help determine potentially significant exposure sources.