IRON OVERLOAD IN BETA(2)-MICROGLOBULIN-DEFICIENT MICE
IRON OVERLOAD IN BETA(2)-MICROGLOBULIN-DEFICIENT MICE
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DOI：
10.1016/0165-2478(94)90094-9
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发表时间：
1994-02-01
影响因子：
4.4
通讯作者：
PORTO, G
中科院分区：
文献类型：
--
作者：
DESOUSA, M;REIMAO, R;PORTO, G
本文对不同年龄的β(2)m-/-和β(2)m+/-小鼠的组织铁分布进行了比较组织学和定量分析。只有突变的β(2)m基因纯合子的小鼠才能发现进行性的肝脏铁超载，这与人类血色素沉着症中观察到的没有区别。火焰原子吸收测定总铁显示，来自5个β(2)m+/-杂合子(468+/-174 mU g/g干重)和9只突变的β(2)m基因纯合小鼠的肝脏样本之间的差异有统计学意义，平均肝总铁水平为1583+/-424 mU g/g干重。
The present paper describes the results of a comparative histological and quantitative analysis of iron distribution in tissues of beta(2)m - / - and beta(2)m + / - mice of different ages. Progressive hepatic iron overload, indistinguishable from that observed in human hemochromatosis, was found only in mice homozygous for the mutated beta(2)m gene. Total iron measurements done by flame atomic absorption showed statistically significant differences between liver samples from 5 beta(2)m + / - heterozygotes (468 +/- 174 mu g/g of dry weight) and 9 mice homozygous for the mutated beta(2)m gene with average total hepatic iron levels of 1583 +/- 424 mu g/g of dry weight.