The Impact of Oligofructose on Stimulation of Gut Hormones, Appetite Regulation and Adiposity
The Impact of Oligofructose on Stimulation of Gut Hormones, Appetite Regulation and Adiposity
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DOI：
10.1002/oby.20754
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发表时间：
2014-06-01
期刊：
影响因子：
6.9
通讯作者：
Frost, Gary S.
中科院分区：
文献类型：
--
作者：
Daud, Norlida M.;Ismail, Nurhafzan A.;Frost, Gary S.
目的：研究低聚果糖对超重和肥胖志愿者的食欲、能量摄入（EI）、体重（BW）和肥胖的影响。方法：在一项平行、单盲和安慰剂对照研究中，22名健康超重和肥胖志愿者被随机分配接受30 g/天（-1）低聚果糖或纤维素，为期6周。在基线和补充后对主观食欲和副作用评分、呼气氢、血清短链脂肪酸（SCFAs）、血浆肠激素、葡萄糖和胰岛素浓度、EI、BW和肥胖进行定量。
Objective: To investigate the effect of nutrient stimulation of gut hormones by oligofructose supplementation on appetite, energy intake (EI), body weight (BW) and adiposity in overweight and obese volunteers.Methods: In a parallel, single-blind and placebo-controlled study, 22 healthy overweight and obese volunteers were randomly allocated to receive 30 g day(-1) oligofructose or cellulose for 6 weeks following a 2-week run-in. Subjective appetite and side effect scores, breath hydrogen, serum short chain fatty acids (SCFAs), plasma gut hormones, glucose and insulin concentrations, EI, BW and adiposity were quantified at baseline and post-supplementation.Results: Oligofructose increased breath hydrogen (P