Duodenal microgastrinoma producing the Zollinger-Ellison syndrome.
Duodenal microgastrinoma producing the Zollinger-Ellison syndrome.
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十二指肠微小胃泌素瘤产生佐林格-埃里森综合征。
DOI：
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发表时间：
1985
影响因子：
4.6
通讯作者：
R. Petras
中科院分区：
文献类型：
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作者：
Z. Vesoulis;R. Petras
在十二指肠溃疡的解剖过程中发现了一个直径1.5毫米的十二指肠壁胃泌素瘤，这位患者后来因大体解剖发现而怀疑为Zollinger-Ellison(ZE)综合征。发现多发性十二指肠溃疡和胃皱胃肥大，免疫组织化学检查证实十二指肠胃泌素瘤相关的壁细胞增生。在许多ZE综合征病例中，原发肿瘤不能通过血管造影术、计算机断层扫描、超声波或探查剖腹探诊来定位。如果肿瘤不能被识别，许多病例将被归因于胰岛细胞增生，或胃泌素细胞(G细胞)增生。此病例证实，原发肿瘤可能大体上无法发现，但仍会产生这种综合征的临床形态表现。
A 1.5-mm gastrinoma of the duodenal wall was discovered during dissection of a duodenal ulcer in a patient in whom the Zollinger-Ellison (ZE) syndrome was later suspected due to gross autopsy findings. Multiple duodenal ulcers and gastric rugal hypertrophy were noted, and hyperplasia of the parietal cells associated with a duodenal gastrinoma was confirmed by immunohistochemical studies. In many cases of ZE syndrome, a primary neoplasm cannot be localized by angiography, computed tomography, ultrasound, or palpation at exploratory laparotomy. If a neoplasm cannot be identified, many cases will be attributed to islet cell hyperplasia, or antropyloric gastrin cell (G cell) hyperplasia. This case confirms that the primary neoplasm may be grossly undetectable and still produce the clinicomorphologic manifestations of this syndrome.