Elevated low-density lipoprotein in Alzheimer's disease correlates with brain Aβ 1-42 levels
Elevated low-density lipoprotein in Alzheimer's disease correlates with brain Aβ 1-42 levels
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DOI：
10.1006/bbrc.1998.9652
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发表时间：
1998-11-27
影响因子：
3.1
通讯作者：
Roher, AE
中科院分区：
文献类型：
--
作者：
Kuo, YM;Emmerling, MR;Roher, AE
对100名个体（64例经神经病理学诊断的阿尔茨海默病（AD）病例和36例非痴呆对照）立即尸检获得的血清进行了胆固醇、脂蛋白、载脂蛋白（Apo）和甘油三酯分析。对所有个体进行ApoE基因分型，并测定AD和对照受试者大脑皮质中A β（N-40和N-42）的含量。与对照组相比，AD患者的LDL胆固醇（P = 0.006）、ApoB（P = 0.018）、A β N-40（P = 0.024）和A β N-42（P < 0.001）显著升高，HDL胆固醇显著降低（P = 0.040）。AD患者血清总胆固醇（r = 0.359，P = 0.004）、低密度脂蛋白胆固醇（r = 0.328，P = 0.008）和载脂蛋白B（r = 0.395，P = 0.001）水平与A β N-42含量呈正相关，但与A β N-40含量无相关性。这些相关性与ApoE基因型无关，在对照组中未观察到。本研究结果首次表明，血清胆固醇升高，特别是以LDL的形式，影响AD相关病理的表达。(C)北京：科学出版社.
Sera obtained in the immediate postmortem from 100 individuals, 64 neuropathologically diagnosed Alzheimer's disease (AD) cases and 36 nondemented controls, were analyzed for cholesterol, lipoproteins, apolipoproteins (Apo), and triglycerides. All individuals ;were ApoE genotyped, and the amounts of A beta (N-40 and N-42) in cerebral cortex of AD and control subjects were determined. When compared to controls, AD individuals had significantly higher LDL cholesterol (P = 0.006), ApoB (P = 0.018), A beta N-40 (P = 0.024) and A beta N-42 (P < 0.001), and significantly lower HDL cholesterol (P = 0.040). There were positive correlations between the levels of serum total cholesterol (r = 0.359, P = 0.004), LDL cholesterol (r = 0.328, P = 0.008), and ApoB (r = 0.395, P = 0.001) to the amount of A beta N-42 in AD brains, but not to A beta N-40. These correlations were independent of ApoE genotype and were not seen in the control group. The present results suggest for the first time that elevated serum cholesterol, especially in the form of LDL, influences the expression of AD-related pathology. (C) 1998 Academic Press.