Evidence for interspecies transmission route of pseudorabies virus via virally contaminated fomites
Evidence for interspecies transmission route of pseudorabies virus via virally contaminated fomites
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DOI：
10.1016/j.vetmic.2020.108912
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发表时间：
2020-12-01
影响因子：
3.3
通讯作者：
Lin, Wencheng
中科院分区：
文献类型：
--
作者：
Li, Hongxin;Liang, Ruiying;Lin, Wencheng
伪狂犬病病毒(PRV)是一种宿主范围很广的人畜共患病病原体，在全球范围内给畜牧业造成巨大的经济损失和潜在的公共卫生风险。这种病原体最近由于在不同物种的动物之间甚至在人类之间的物种间传播而受到关注。虽然PRV在许多动物物种中都有流行，但无论涉及的毒株是疫苗、经典毒株还是变异毒株，关于病毒传播途径的证据很少。在这里，我们报告了病毒污染与PRV的跨物种传播有关。我们发现，PRV污染广泛分布在养猪场的环境中，环境中的病毒分布与生物安全措施的实施有关，PRV可以通过受病毒污染的杂合体从猪传播给狗。总而言之，我们的发现为了解PRV的生态和传播途径提供了基础，并强调了实施生物安全措施控制这种疾病的重要性。
Pseudorabies virus (PRV) is a zoonotic agent with a wide host range, causing significant economic losses in animal husbandry and potential public health risk globally. The causative agent has recently gained attention due to the inter-species transmission among different species of animals, even human beings. Although PRV's prevalence is found in many species of animals, regardless of whether the strain involved is a vaccine, classical or variant, few lines of evidence for the viral transmission route are available. Here, we reported that viral contamination is associated with the inter-species transmission of PRV. We found that PRV contamination was widely distributed in the environment of pig farms, that viral distribution in the environment is associated with the implementation of biosecurity measures, and that PRV could transmit from pigs to dogs through virally contaminated fomites. Collectively, our findings provide a basis for understanding the ecology and transmission route of PRV and underscore the importance of implementing biosecurity measures to control this disease.