Effects of alpha adrenoreceptor antagonists, prazosin and yohimbine, on intrathecal lidocaine‐induced antinociception in mice
Effects of alpha adrenoreceptor antagonists, prazosin and yohimbine, on intrathecal lidocaine‐induced antinociception in mice
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DOI：
10.1034/j.1399-6576.2000.440908.x
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发表时间：
2000-10
影响因子：
2.1
通讯作者：
Y. Uchihashi;M. Kamei;I. Fukuda;T. Nakai;F. Karasawa;T. Satoh
中科院分区：
文献类型：
--
作者：
Y. Uchihashi;M. Kamei;I. Fukuda;T. Nakai;F. Karasawa;T. Satoh
背景：利多卡因脊柱镇痛作用的确切机制尚不清楚。我们之前发现利多卡因在大鼠脊髓中释放一种痛觉调节剂去甲肾上腺素。在这里，我们试图澄清去甲肾上腺素的释放是否有助于利多卡因的脊髓镇痛。
Background: The precise mechanisms involved in the spinal analgesic effect of lidocaine are not yet clear. We previously found that lidocaine releases noradrenaline, a modulator of nociception, in rat spinal cord. Here, we attempted to clarify whether or not the noradrenaline release contributes to spinal analgesia by lidocaine.