The periodic focusing ion funnel: theory, design, and experimental characterization by high-resolution ion mobility-mass spectrometry.
The periodic focusing ion funnel: theory, design, and experimental characterization by high-resolution ion mobility-mass spectrometry.
复制标题
DOI：
10.1021/ac401629b
复制
发表时间：
2013-10
影响因子：
7.4
通讯作者：
Kyle L. Fort;Joshua A. Silveira;D. Russell
中科院分区：
文献类型：
--
作者：
Kyle L. Fort;Joshua A. Silveira;D. Russell
本文描述了仅DC离子漏斗的基于模拟的开发和实验表征。径向离子约束通过周期性聚焦实现，由此在以可观速度穿过装置的离子的惯性系中产生碰撞阻尼的有效电势。新设备，称为周期性聚焦离子漏斗（PF IF），提供了一个有效的替代射频离子漏斗提供高离子传输与更少的电极，简化电路，并降低电源要求。使用模型肽离子（缓激肽，短杆菌肽S，和trpzip 1）的结构离子迁移率-质谱（IM-MS）研究的PF IF的效用证明。
Simulation-based development and experimental characterization of a DC-only ion funnel is described herein. Radial ion confinement is achieved via periodic focusing whereby a collisionally dampened effective potential is generated in the inertial frame of an ion traversing the device with appreciable velocity. The new device, termed a periodic focusing ion funnel (PF IF), provides an efficient alternative to the rf ion funnel providing high ion transmission with fewer electrodes, simplified electrical circuitry, and reduced power supply requirements. The utility of the PF IF for structural ion mobility-mass spectrometry (IM-MS) studies is demonstrated using model peptide ions (bradykinin, gramicidin S, and trpzip 1).