Miniaturized fiber-optic hybrid sensor for continuous glucose monitoring in subcutaneous tissue
Miniaturized fiber-optic hybrid sensor for continuous glucose monitoring in subcutaneous tissue
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DOI：
10.1016/j.snb.2006.05.010
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发表时间：
2007-03-08
影响因子：
8.4
通讯作者：
Schaupp, Lukas
中科院分区：
文献类型：
--
作者：
Pasic, Alen;Koehler, Hans;Schaupp, Lukas
介绍了一种用于连续测量皮下组织葡萄糖的新型光纤微传感器。该混合传感器由两个氧光电二极管组成，其中一个光电二极管含有固定化葡萄糖氧化酶。葡萄糖信号是两个光电二极管pO(2)之间的差异，可以补偿细胞间液中的氧波动。基于氧依赖对传感器响应的研究结果，通过增厚扩散屏障对葡萄糖敏感光电器件进行了优化。在低氧浓度下，氧传感器灵敏度的提高弥补了葡萄糖传感分辨率的损失。优化后的传感器在53至95 hPa的预期pO(2)范围内没有氧气波动，传感器输出在生理相关葡萄糖范围内呈线性，最高可达20 mM。参考氧传感器的使用还允许补偿轻微的温度波动。(c) 2006 Elsevier B.V.版权所有
A new optical fiber microsensor for continuous measurement of glucose in subcutaneous tissue is described. The hybrid sensor consists of two oxygen optodes wherein one optode contains immobilized glucose oxidase. The glucose signal which is a difference between pO(2) of both optodes allows the compensation of oxygen fluctuations in intercellular fluid. Based on the results of investigations of the oxygen dependence on sensor response, the optimization by thickening the diffusion barrier of glucose sensitive optode is done. The loss of the sensing resolution for glucose is compensated by the increased sensitivity of the oxygen transducer at the low oxygen concentrations. The optimized sensor is free of oxygen fluctuations in the expected pO(2) range between 53 and 95 hPa and the sensor output is linear in the physiological relevant glucose range up to 20 mM. The use of the reference oxygen sensor allows also the compensation of the slight temperature fluctuations. (c) 2006 Elsevier B.V. All rights reserved.