Nicotine increases alcohol self-administration in non-dependent male smokers
Nicotine increases alcohol self-administration in non-dependent male smokers
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DOI：
10.1016/j.drugalcdep.2005.06.009
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发表时间：
2006-02-01
影响因子：
4.2
通讯作者：
Pihl, RO
中科院分区：
文献类型：
--
作者：
Barrett, SP;Tichauer, M;Pihl, RO
背景资料：酒精和烟草通常是共同管理，但很少有人知道急性尼古丁管理对人类饮酒的影响。本研究旨在确定如何尼古丁提供烟草烟雾影响酒精摄入量在人类使用双盲安慰剂对照重复measurements design.Methods：在两个随机120分钟的会议15名男性偶尔吸烟者吸烟四尼古丁含或4 denicotinized香烟在30分钟的间隔。在整个会议期间，受试者可以赚取他们的首选酒精饮料和玻璃杯的水单位使用累进比（PR）task.Results：Wilcoxon符号秩检验表明，尼古丁增加酒精自我管理在一个显着比例的参与者（P < 0.03），而不影响水的消耗（P >= 0.16）。双向方差分析进一步支持了这一观察结果，并且，与去尼古丁香烟相比，含尼古丁香烟增加了酒精的PR断点，但不增加水的PR断点，正如香烟x饮料相互作用所反映的那样（P
Background: Alcohol and tobacco are commonly co-administered, yet little is known about the effects of acute nicotine administration on alcohol consumption in humans. This study sought to determine how nicotine delivered by tobacco smoke influences alcohol intake in humans using a double-blind placebo controlled repeated measures design.Methods: During two randomized 120 min sessions 15 male occasional smokers smoked four nicotine-containing or four denicotinized cigarettes at 30 min intervals. Throughout the session, subjects could earn units of their preferred alcoholic beverage and glasses of water using a progressive-ratio (PR) task.Results: Wilcoxon signed-rank tests indicated that nicotine increased alcohol self-administration in a significant proportion of participants (P < 0.03) without affecting water consumption (P >= 0.16). A two-way ANOVA Supported this observation further, and, compared to denicotinized cigarettes, the nicotine-containing cigarettes increased PR breakpoints for alcohol but not water, as reflected by a Cigarette x Beverage interaction (P