Maternal serum leptin as a marker of preeclampsia
Maternal serum leptin as a marker of preeclampsia
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DOI：
10.1007/s00404-013-2915-8
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发表时间：
2013-12-01
影响因子：
2.6
通讯作者：
Mohamed, Heba Saber
中科院分区：
文献类型：
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作者：
El Shahat, Amal Mohamed;Ahmed, Abeer Bahaa;Mohamed, Heba Saber
为评价母体瘦素水平作为子痫前期(PE)标志物的价值，探讨瘦素作为子痫前期严重程度标志物的可能性，对72例妊娠28~38周的孕妇进行了前瞻性对照研究。根据先兆子痫的临床参数是否存在，将其分为两组(对照组和研究组)。两组在分娩时、每周一次和终止妊娠时测量瘦素。研究发现，与对照组相比，所有先兆子痫患者的瘦素水平都显著高于对照组；无论是入院时还是分娩时。对照组入院时平均血清瘦素水平为9.8 ng/ml，轻度组为10.9 ng/ml，重度组为17.6 ng/ml。分娩时，对照组平均血清瘦素水平降至4.7 ng/ml，而先兆子痫组轻度升高至22 ng/ml，重度升高至42.6 ng/ml。ROC曲线分析显示，以<13.7 ng/ml为临界值，诊断子痫前期的敏感性为91%，特异性为100%；以<22.5 ng/ml为临界值，可判断子痫前期的严重程度，敏感性为85%，特异性为100%。子痫前期孕妇血清瘦素水平显著升高，可作为子痫前期存在的标志物，用于轻度子痫前期和重度子痫前期的鉴别。
To assess maternal leptin levels as a marker for preeclampsia (PE) and to explore the possibility of leptin being a marker of severity of preeclampsia.Comparative prospective study was conducted among a total of 72 pregnant women at 28-38 weeks of gestation. They were divided into two groups (control and study) according to the absence or presence of clinical parameters of preeclampsia. Leptin was measured for both groups at the time of presentation, once weekly and at the termination of pregnancy.Leptin levels were found to be significantly higher among all preeclampsia patients when compared to the control group; whether at admission or at the time of delivery. Mean serum leptin level at admission in control group was 9.8 ng/ml versus 10.9 ng/ml in mild cases and 17.6 ng/ml in severe cases. At the time of delivery, mean serum leptin in control group decreased to 4.7 ng/ml while in preeclampsia patients it increased up to 22 ng/ml in mild cases and 42.6 ng/ml in severe cases. ROC curve analysis has shown that a cut off value > 13.7 ng/ml can be used to detect presence of preeclampsia with a sensitivity of 91 % and specificity 100 % while a cut off value > 22.5 ng/ml can be used to detect severity of preeclampsia with a sensitivity of 85 % and specificity 100 %.Maternal serum leptin is significantly elevated in preeclampsia, also it can be used as a marker for the presence of preeclampsia and to differentiate patients with mild preeclampsia from those with severe disease.