Functional anatomy of GO/NO-GO discrimination and response selection - A PET study in man
Functional anatomy of GO/NO-GO discrimination and response selection - A PET study in man
复制标题
DOI：
10.1016/0006-8993(96)00389-7
复制
发表时间：
1996-07-22
期刊：
影响因子：
2.9
通讯作者：
Fukuda, H
中科院分区：
文献类型：
--
作者：
Kawashima, R;Satoh, K;Fukuda, H
本研究的目的是确定与NO-GO决定相关的激活功能场。9名健康受试者参与研究，包括2次正电子发射断层扫描（PET）测试（GO/NO-GO任务和反应选择任务）和1次对照扫描。在反应选择任务中，受试者被要求当距离他们眼睛60厘米的发光二极管（LED）亮起红色时弯曲右手拇指，当LED亮起绿色时弯曲右手食指。在GO/NO-GO任务中，当LED显示为红色时，受试者被要求弯曲拇指，然而，当LED显示为绿色时，受试者被要求不要移动手指。在控制状态下，他们被要求在扫描过程中仅仅看着LED，手指没有任何运动。计算各任务减去控制和任务减去任务时的平均区域脑血流（rCBF）变化图像，并确定显著的rCBF变化区域。右半球前额叶皮层的几个区域在GO/NO-GO任务中被特别激活。结果表明，右半球前额叶皮层可能是决定不动的关键结构。
The purpose of this study was to identify the functional fields activated in relation to the NO-GO decision. Nine healthy subjects participated in the study which consisted of two test positron emission tomography (PET) scans (GO/NO-GO task and response selection task) and one control scan. In the response selection task, subjects were asked to flex their thumb of the right hand when a light emitting diode (LED) placed 60 cm from their eyes turned on red and to flex their index finger of the right hand when LED turned on green. In the GO/NO-GO task, subjects were asked to flex their thumb when the LED turned on red, however, they were asked not to move their fingers when LED turned on green. In the control state, they were asked simply to look at the LED without any movement of finger during the course of the scan. The mean regional cerebral blood flow (rCBF) change images for each task minus control and task minus task were calculated and fields of significant rCBF changes were identified.Several fields in the prefrontal cortex of the right hemisphere were specifically activated in relation to the GO/NO-GO task. The results indicate that the prefrontal cortex of the right hemisphere may be a key structure to make a decision not to move.