Office-based simple frailty score and central blood pressure predict mild cognitive impairment in an apparently healthy Japanese population: J-SHIPP study.
Office-based simple frailty score and central blood pressure predict mild cognitive impairment in an apparently healthy Japanese population: J-SHIPP study.
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DOI：
10.1038/srep46419
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发表时间：
2017-04-13
影响因子：
4.6
通讯作者：
Igase M
中科院分区：
文献类型：
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作者：
Ohara M;Kohara K;Okada Y;Ochi M;Nagai T;Ohyagi Y;Tabara Y;Igase M
虚弱与认知障碍有关，可用于识别痴呆症高危人群。我们开发了一个简单的虚弱（SF）评分，使用低手握力（男性<32.5 kg，女性<19.5 kg）和短单腿站立时间（<20秒）的组合。这些可以很容易地测量在临床医生的办公室时，看到病人。我们在一项横断面研究中调查了SF评分与轻度认知功能障碍（MCI）之间的可能联系，该研究有838名独立的中老年参与者（319名男性，平均年龄65.1岁）。共有118名参与者被诊断为MCI。SF评分为2与MCI的存在显著相关（比值比4.6，95%置信区间：1.9-6.9，p = 0.0001），即使在调整年龄和性别后。逐步回归分析显示，SF评分为2与MCI的存在相关，独立于中心脉压和无症状性脑梗死。这些结果表明，SF评分是一个有用的脆弱性参数，预测MCI在一个明显独立的人口。
Frailty is associated with cognitive impairment and can be used to identify people at high risk for dementia. We developed a simple frailty (SF) score using a combination of low hand grip strength (<32.5 kg in men, <19.5 kg in women), and short one-leg standing time (<20 seconds). These can be easily measured in the clinician’s office when seeing patients. We investigated the possible association between SF score and mild cognitive impairment (MCI) in a cross-sectional study with 838 independent middle-aged to elderly participants (319 men, mean age 65.1years). In total, 118 participants were diagnosed with MCI. A SF score of 2 was significantly associated with the presence of MCI (odds ratio 4.6, 95% confidence interval: 1.9–6.9, p = 0.0001) even after adjustment for age and sex. Stepwise regression analyses showed that a SF score of 2 was associated with the presence of MCI, independently of central pulse pressure and silent cerebral infarcts. These findings indicate that the SF score is a useful frailty parameter to predict MCI in an apparently independent population.