SARS-CoV-2 Infectivity and Antibody Titer Reduction for 6 Months After Second Dose of BNT162b2 mRNA Vaccine in Health Care Workers: A Prospective Cohort Study
SARS-CoV-2 Infectivity and Antibody Titer Reduction for 6 Months After Second Dose of BNT162b2 mRNA Vaccine in Health Care Workers: A Prospective Cohort Study
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DOI：
10.1093/infdis/jiac035
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发表时间：
2022-02-01
影响因子：
6.4
通讯作者：
Park, Hyunwoong
中科院分区：
文献类型：
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作者：
Kim, Namhee;Shin, Sue;Park, Hyunwoong
几项研究报告说，在接种疫苗的参与者中，严重急性呼吸综合征冠状病毒-2抗体水平在6个月内发生变化。从登记的272名卫生保健工作者（HCWs）中，在第二次疫苗接种后2周、16周和24周采集了血液样本。在267例未感染的HCWs中，中和抗体在24周时下降了23.9%，抗刺突/受体结合域抗体下降了53.8%。我们观察到两性之间在抗体减少方面没有显著差异；然而，在年轻的个体中，有较高的抗体形成和较低的中和抗体还原率。在3例突破性感染的卫生保健中心中，抗体水平在2019冠状病毒病感染前相对较低。综上所述，由于第二次疫苗接种后抗体滴度会随着时间的推移而降低，而抗体滴度较低的HCWs发生突破性感染的可能性较大，因此应考虑在几个月后再接种一次。在第二次接种疫苗后2周、16周和24周，从卫生保健工作者处采集血液样本。抗体滴度随着时间的推移而降低，抗体滴度低的参与者往往有很高的突破感染的可能性。
Several studies reported that severe acute respiratory syndrome coronavirus-2 antibody levels change over 6 months in participants receiving the vaccination. From the enrolled 272 health care workers (HCWs), blood samples were obtained at 2, 16, and 24 weeks after the second vaccination dose. In the 267 noninfected HCWs, the neutralizing antibodies decreased by 23.9%, and the anti-spike/receptor binding domain antibody decreased by 53.8% at 24 weeks. We observed no significant difference in antibody reduction between the sexes; however, in younger individuals, there was higher antibody formation and lower reduction rates of the neutralizing antibody. In 3 HCWs with breakthrough infections, the antibody levels were relatively low just before the coronavirus disease 2019 infection. In conclusion, as antibody titers decrease over time after the second vaccination dose and HCWs with low antibody titers tend to have a high probability of breakthrough infection, an additional dose should be considered after several months. Blood samples were obtained from health care workers at 2, 16, and 24 weeks after a second vaccination dose. Antibody titers decreased over time and the participants with low antibody titers tended to have a high probability of breakthrough infection.