Characteristics of Devic's disease (neuromyelitis optica) in Mexico
Characteristics of Devic's disease (neuromyelitis optica) in Mexico
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DOI：
10.1007/s00415-008-0781-2
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发表时间：
2008-05-01
影响因子：
6
通讯作者：
Corona V., Teresa
中科院分区：
文献类型：
--
作者：
Flores Rivera, Jose;Kurtzke, John F.;Corona V., Teresa
目的报告墨西哥Devic病的临床和流行病学资料。设计回顾性研究医院病历。研究对象为墨西哥城的三级医疗转诊中心--国家神经病学和神经外科研究所（INNN）的病历。在561例诊断为多发性硬化症（MS）、视神经肌萎缩症（NMO）或等同疾病的出院患者中，有424例病史可供审查。390例符合MS诊断标准，34例符合NMO诊断标准。主要结果测量我们记录了临床体征、视力和扩展残疾状态量表（EDSS）在最初诊断入院时和随访期间。所有患者均在诊断时进行脑脊液（CSF）检查;在诊断和随访时进行头部和脊柱磁共振成像（MRI）。结果34例患者均为墨西哥混血儿，占墨西哥城居民的79%。有23例为双相和复发病例。8例ON和12例肌无力发作的初始和定义事件之间的间隔分别为17和24个月（平均值）和15和17个月（中位数）。从发病开始的平均随访时间为70.2个月，从诊断检查开始的平均随访时间为42.9个月。无患者显示EDSS评分改善。视力严重丧失。结论初步估计墨西哥混血儿NMO患病率为1/10万。在我们的人群中，这种疾病似乎比最近的其他系列更严重。
Objective To report clinical and epidemiological data of Devic's disease in Mexico. Design Retrospective study of hospital case records. Setting The medical records were those of the National Institute for Neurology and Neurosurgery (INNN), a tertiary care referral center in Mexico City. Patients There were 424 medical histories available for review among 561 discharges with diagnoses of multiple sclerosis (MS), neuromyelitis optica (NMO), or equivalents. 390 met the diagnostic criteria of MS and 34 the NMO criteria. Main outcome measures We recorded clinical signs, visual acuities, and the Expanded Disability Status Scale (EDSS) at the initial diagnostic admission and during follow-up. All patients had examination of cerebrospinal fluid (CSF) at diagnosis; head and spine magnetic resonance imaging (MRI) were performed at diagnosis and at follow-up. Results All 34 patients were Mexican Mestizos, who comprise 79% of the residents of Mexico City. There were 23 monophasic and I I relapsing cases. Intervals between initial and defining events for the 8 ON and 12 myelitis onsets were 17 and 24 months (means) and 15 and 17 months (medians), respectively. Mean follow-up from onset was 70.2 months and 42.9 months from diagnostic examination. No patient showed improvement in EDSS scores. Visual loss was severe. Conclusion A provisional prevalence rate of about I per 100,000 population for NMO in Mexican Mestizos might be offered. The disease seems more severe in our population than in other recent series.