Influence of glucocorticoids on time-of-day-dependent variations in IgE-, histamine-, and platelet-activating factor-mediated systemic anaphylaxis in different mouse strains
Influence of glucocorticoids on time-of-day-dependent variations in IgE-, histamine-, and platelet-activating factor-mediated systemic anaphylaxis in different mouse strains
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DOI：
10.1016/j.bbrc.2017.12.099
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发表时间：
2018-01-15
影响因子：
3.1
通讯作者：
Ohmori, Keitaro
中科院分区：
文献类型：
--
作者：
Hasegawa, Ayana;Watanabe, Miwa;Ohmori, Keitaro
在ICR小鼠中，先前报道了IgE介导的被动全身过敏反应的一种时间依赖的变异。在本研究中，我们研究了C57BL/6、BALB/c和NC/Nga小鼠在9：00和21：00由IgE、组胺和血小板激活因子(PAF)介导的全身过敏反应的时间依赖性变化，并评估了糖皮质激素(GCs)对这些变化的潜在影响。我们发现，在C57BL/6小鼠中，IgE介导的全身过敏反应以及在BALB/c小鼠中，组胺和PAF介导的全身过敏反应具有显著的时间依赖性变化。在NC/NGA小鼠中，没有观察到IgE、组胺和PAF介导的全身性过敏反应的显著日变化。地塞米松和肾上腺切除可消除C57BL/6小鼠IgE介导的全身性过敏反应和PAF介导的BALB/c小鼠全身性过敏反应的日变化，提示来自肾上腺的GCs在调节这些变化中起关键作用。相反，地塞米松和肾上腺切除并不能消除BALB/c小鼠组胺介导的全身性过敏反应的每日变化，这表明GC非依赖和肾上腺非依赖的机制对这种变化是重要的。目前的研究表明，全身性过敏反应的时间依赖变化在近交系小鼠品系和过敏诱导物质之间是不同的。因此，为了获得合适的实验结果，必须考虑小鼠品系、实验时间和所使用的过敏反应诱导物质。(C)2017 Elsevier Inc.保留所有权利。
A time-of-day-dependent variation in IgE-mediated passive systemic anaphylaxis was previously reported in ICR mice. In the present study, we investigated time-of-day-dependent variations in IgE-, histamine-, and platelet-activating factor (PAF)-mediated systemic anaphylaxis in C57BL/6, BALB/c, and NC/Nga mice at 9:00 h and 21:00 h, and evaluated the potential influence of glucocorticoids (GCs) on these variations. We found significant time-of-day-dependent variations in IgE-mediated systemic anaphylaxis in C57BL/6 mice, and in histamine- and PAF-mediated systemic anaphylaxis in BALB/c mice. Significant daily variations in IgE-, histamine-, and PAF-mediated systemic anaphylaxis were not observed in NC/Nga mice. Pretreatment with dexamethasone and adrenalectomy abolished the daily variations in IgE-mediated systemic anaphylaxis in C57BL/6 mice and in PAF-mediated systemic anaphylaxis in BALB/c mice, suggesting that GCs from adrenal glands are pivotal in regulating these variations. In contrast, pretreatment with dexamethasone and adrenalectomy did not abolish the daily variation in histamine-mediated systemic anaphylaxis in BALB/c mice, suggesting that GC-independent and adrenal gland-independent mechanisms are important for the variation. The present study demonstrated that time-of-day-dependent variations in systemic anaphylaxis differed among inbred mouse strains and with anaphylaxis-inducing substances. Thus, mouse strains, time of experiment, and anaphylaxis-inducing substances used must be considered to obtain appropriate experimental results. (C) 2017 Elsevier Inc. All rights reserved.