A Mild and Regiospecific Synthesis of Pyrazoleboranes
A Mild and Regiospecific Synthesis of Pyrazoleboranes
复制标题
DOI：
10.1002/chem.201701019
复制
发表时间：
2017-04-19
影响因子：
4.3
通讯作者：
Harrity, Joseph P. A.
中科院分区：
文献类型：
--
作者：
Brown, Andrew W.;Comas-Barcelo, Julia;Harrity, Joseph P. A.
炔基硼烷在它们的[4+2]环加成反应中显示出前所未有的反应性，在室温下在几小时内提供完全取代的吡唑。该方法提供了具有合成价值的吡唑硼烷，具有完全的区域选择性控制，并且这些中间体可以通过C-B键的官能化进一步加工。
Alkynylboranes show unprecedented reactivity in their [4+2] cycloaddition of sydnones offering access to fully substituted pyrazoles within a few hours at room temperature. This method delivers synthetically valuable pyrazoleboranes with complete control of regioselectivity, and these intermediates can be further elaborated through functionalization of the C-B bond.