Planar cell polarity: two genetic systems use one mechanism to read gradients
Planar cell polarity: two genetic systems use one mechanism to read gradients
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DOI：
10.1242/dev.168229
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发表时间：
2018-12-01
期刊：
影响因子：
4.6
通讯作者：
Casal, Jose
中科院分区：
文献类型：
--
作者：
Lawrence, Peter A.;Casal, Jose
我们在这篇简短的入门读物中的目的是解释动物发育中平面细胞极性 (PCP) 的原理。这个小领域的文献既复杂又专业，但我们从中提取了一个简单而中心的故事。我们解释了我们的假设，即最初由多细胞梯度的斜率方向提示的极性在细胞水平上被解释，以便每个细胞变得分子极化。该机制涉及细胞与其邻近细胞之间的比较。为了实现这种比较，（至少）有两个不同且独立的分子系统，每个系统都依赖于跨越相邻细胞之间的分子桥。尽管这两个系统由不同的分子组成，但我们认为这两个系统以逻辑上等效的方式发挥作用。
Our aim in this short Primer is to explain the principles of planar cell polarity (PCP) in animal development. The literature in this small field is complex and specialized, but we have extracted a simple and central story from it. We explain our hypothesis that polarity, initially cued by the direction of slope of a multicellular gradient, is interpreted at the cellular level so that each cell becomes molecularly polarised. The mechanism involves a comparison between a cell and its neighbours. To achieve this comparison there are (at least) two disparate and independent molecular systems, each depending on molecular bridges that span between neighbouring cells. Even though the two systems are made up of different molecules, we argue that both systems function in a logically equivalent way.