Seroprevalence of five arboviruses in Zebu cattle in the Central African Republic
Seroprevalence of five arboviruses in Zebu cattle in the Central African Republic
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DOI：
10.1016/s0035-9203(96)90468-x
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发表时间：
1996-01-01
影响因子：
2.2
通讯作者：
Vincent, J
中科院分区：
文献类型：
--
作者：
Guilherme, JM;GonellaLegall, C;Vincent, J
用酶联免疫吸附试验检测了237头成年泽布牛和147头幼年泽布牛的血清中裂谷热(RVF)、杜格贝(Dugbe)、克里米亚-刚果出血热(CCHF)、基孔肯雅(CHIK)和韦塞尔斯布隆(WSL)病毒的抗体。成年牛血清中分别有70%和61%检测到DUG和CCHF病毒抗体，这可能是由于共同的抗原引起的。这一假说得到以下事实的支持：CCHF病毒仅从硬蜱中分离到3次，而DUG病毒几乎从所有硬蜱中分离到。扁虱是CCHF最重要的媒介，在汽车上的斑马虫上很少见。CCHF病毒在人类局部病理中的作用有限，可能是因为其主要载体的稀缺性以及DUG病毒抗体的存在导致的免疫屏障限制了它的分布。在大约8%的成年牛身上发现了裂谷热病毒抗体。Zebus在CHIK和WSL病毒在人类之间的传播中没有发挥重要作用；在被检查的183头牛中，分别只有1头和5头发现了这两种病毒。
Sequential blood samples taken from 237 adult and 147 young Zebu cattle in the Central African Republic (CAR) were examined by enzyme-linked immunosorbent assay for the presence of antibodies to Rift Valley Fever (RVF), Dugbe (DUG), Crimean-Congo haemorrhagic fever (CCHF), Chikungunya (CHIK) and Wesselsbron (WSL) viruses. Antibodies to DUG and CCHF viruses were detected in 70% and 61% respectively, of the sera from adult cattle, probably due to common antigens. This hypothesis is supported by the fact that CCHF virus was isolated only 3 times from ticks, whereas DUG virus was isolated from almost all ticks. Ticks of the genus Hyalorama, the most important vectors of CCHF, are rare on Zebus in CAR. CCHF virus has a limited role in local human pathology, probably because its distribution is limited by the scarcity of its main vector and the immunological barrier resulting from the presence of antibodies to DUG virus. Antibodies to RVF virus were found in about 8% of adult cattle. Zebus do not play an important role in the spread of CHIK and WSL viruses among humans; these viruses were found in only one and 5, respectively, of the 183 cattle examined.