Time-domain diffuse correlation spectroscopy.
Time-domain diffuse correlation spectroscopy.
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DOI：
10.1364/optica.3.001006
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发表时间：
2016-09
期刊：
影响因子：
10.4
通讯作者：
Franceschini MA
中科院分区：
文献类型：
--
作者：
Sutin J;Zimmerman B;Tyulmankov D;Tamborini D;Wu KC;Selb J;Gulinatti A;Rech I;Tosi A;Boas DA;Franceschini MA
脑部供氧的生理监测对于改善脑损伤风险患者的管理具有重要意义。漫相关光谱 (DCS) 是一种快速发展的光学技术，能够在床边无创地评估血流指数 (BFi)。 DCS 目前的局限性是脑外组织引入的污染以及需要了解组织的光学特性以正确量化 BFi。为了克服这些限制，我们开发了一种时间分辨漫相关光谱新技术。通过在时域中操作 DCS (TD-DCS)，我们能够同时获取用于量化组织光学特性的时间点扩展函数和用于量化 BFi 的自相关函数。更重要的是，通过将时间选通策略应用于 DCS 自相关函数，我们能够区分穿过组织的短光子路径和长光子路径，并确定不同深度的 BFi。在这里，我们展示了这种新颖的装置，并报告了在组织样体模和啮齿动物中的首次实验。 TD-DCS 方法为改进人体氧气输送的无创监测提供了许多可能性。
Physiological monitoring of oxygen delivery to the brain has great significance for improving the management of patients at risk for brain injury. Diffuse correlation spectroscopy (DCS) is a rapidly growing optical technology able to non-invasively assess the blood flow index (BFi) at the bedside. The current limitations of DCS are the contamination introduced by extracerebral tissue and the need to know the tissue’s optical properties to correctly quantify the BFi. To overcome these limitations, we have developed a new technology for time-resolved diffuse correlation spectroscopy. By operating DCS in the time domain (TD-DCS), we are able to simultaneously acquire the temporal point-spread function to quantify tissue optical properties and the autocorrelation function to quantify the BFi. More importantly, by applying time-gated strategies to the DCS autocorrelation functions, we are able to differentiate between short and long photon paths through the tissue and determine the BFi for different depths. Here, we present the novel device and we report the first experiments in tissue-like phantoms and in rodents. The TD-DCS method opens many possibilities for improved non-invasive monitoring of oxygen delivery in humans.